Thalidomide-O-PEG4-Propargyl
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Category：Biomedicine
Introduction
CAS NO.: 2098799-77-8
Product purity: ≥95%
Molecular formula: C24H28N2O9
Molecular weight: 488.49
Product Usage: Applied to medical research, drug release, nanotechnology and new material research, cell culture. As well as in ligand research, peptide synthesis support, grafted polymer compounds, new materials and polyethylene glycol modified functional coatings and other active compounds.
Basic Information
| Item | Description |
|---|---|
| Full Name | Thalidomide-O-PEG4-Propargyl |
| CAS Number | 2098799-77-8 |
| Molecular Formula | C24H28N2O9 |
| Molecular Weight | 488.5 g/mol |
| Purity | ≥95% |
| Appearance | White to off-white solid or powder |
| Solubility | Soluble in water, DMSO, DMF, DCM |
| Storage Conditions | -5°C, dry, protected from light |
Detailed Information
| Item | Description |
|---|---|
| Structure | Thalidomide core linked to a PEG chain with four ethylene oxide units and a propargyl (alkyne) group at the end |
| Reactivity | The propargyl group can undergo click chemistry reactions with azides in the presence of a copper catalyst to form stable triazole linkages |
| Applications | – PROTAC Technology: Used as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.<br>- Medical Research: Applied in drug release, nanotechnology, and cell culture.<br>- Material Science: Used in the synthesis of functional coatings and polymers. |
| Advantages | – Combines the properties of Thalidomide, PEG, and a reactive propargyl group.<br>- High biocompatibility and versatility in bioconjugation. |
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