3-Chloro-2-fluoro-4-iodopyridine
Biomedicine 2025-03-04
CAS.No：796851-05-3
Appearance:White powder
Molecular Formula:C5H2ClFIN
Purity:≥99.5%
Molecular weight :257.43
Capacity:20 tons/month
Application:Pharmaceutical intermediates
Basic Information of 3-Chloro-2-Fluoro-4-Iodopyridine
| Aspect | Details |
|---|---|
| Chemical Name | 3-Chloro-2-Fluoro-4-Iodopyridine |
| CAS Number | 796851-05-3 |
| Molecular Formula | C₅H₂ClFIN |
| Molecular Weight | 257.43 g/mol |
| Appearance | White to light yellow crystalline powder |
| Melting Point | 98-99°C |
| Boiling Point | 254.8±35.0 °C (Predicted) |
| Density | 2.129±0.06 g/cm³ (Predicted) |
| Solubility | Soluble in common organic solvents like methanol and DMSO |
| Storage Conditions | Store under inert gas (nitrogen or argon) at 2–8°C |
| pKa | -4.10±0.18 (Predicted) |
Additional Information on 3-Chloro-2-Fluoro-4-Iodopyridine
| Aspect | Details |
|---|---|
| Synonyms | 2-Fluoro-3-chloro-4-iodopyridine, Pyridine, 3-chloro-2-fluoro-4-iodo- |
| Applications | – Pharmaceutical Intermediate: Used in the synthesis of various pharmaceutical compounds .<br>- Organic Synthesis: Serves as a building block for the synthesis of more complex organic molecules .<br>- Agrochemical Intermediate: Used in the synthesis of pesticides and herbicides . |
| Safety Information | – Hazard Codes: Xi (Irritant) .<br>- Storage: Store in a cool, dry place. Keep container tightly closed in a dry place .<br>- Personal Protection: Wear protective gloves, eye protection, and respiratory protection . |
| Synthesis | – Typically synthesized via a multi-step process involving lithium-halogen exchange and iodination reactions .<br>- Example route: 3-chloro-2-fluoropyridine reacts with n-butyllithium in THF at -78°C, followed by iodination . |
| Packaging and Price | – 100mg: $27 (Anjia) <br>- 250mg: $102 (Alfa Aesar) <br>- 1g: $29 (Bide) |
| Purity | ≥98% |
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