Tos-PEG2-NH2
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Category：Biomedicine MOQ:100KG Shipped directly from China
Introduction
CAS NO.: 1246286-33-8
Product purity: ≥95%
Molecular formula: C11H17NO4S
Molecular weight: 259.32
Product Usage: Used in medical research, drug release, nanotechnology and new material research, cell culture. As well as in ligand research, peptide synthesis support, grafted polymer compounds, new materials and polyethylene glycol modified functional coatings and other active compounds.
Basic Information
| Item | Description |
|---|---|
| Full Name | Tosyl-PEG2-Amine |
| CAS Number | 1246286-33-8 |
| Molecular Formula | C11H17NO4S |
| Molecular Weight | 259.32 |
| Purity | ≥95% |
| Appearance | White to off-white solid or viscous liquid |
| Solubility | Soluble in water, DMSO, DMF, DCM |
| Storage Conditions | -5°C, dry, protected from light |
Detailed Information
| Item | Description |
|---|---|
| Structure | Consists of a PEG chain with two ethylene oxide units, an amino group (NH2) at one end, and a tosylate (Tos) group at the other end |
| Reactivity | The amino group can react with carboxyl groups to form amide bonds, with aldehydes to form Schiff bases, or with other activated groups. The tosylate group is a good leaving group for nucleophilic substitution reactions |
| Applications | – PROTAC Synthesis: Used as a linker in the synthesis of Proteolysis-Targeting Chimeras (PROTACs) for selective protein degradation.<br>- Bioconjugation: Modifies proteins, peptides, and other biomolecules to improve stability and reduce immunogenicity.<br>- Drug Delivery: Enhances drug stability and targeting.<br>- Surface Modification: Improves biocompatibility of nanoparticles and other materials.<br>- Material Science: Used in the synthesis of functional coatings and polymers. |
| Advantages | High biocompatibility, good water solubility, and versatile reactivity. The PEG chain enhances stability and reduces immunogenicity |
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