Thalidomide-O-PEG4-SPA
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Category：Biomedicine Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS NO.: 2411681-88-2
Product purity: ≥95%
Molecular formula: C28H33N3O13
Molecular weight: 619.57
Product Usage: Used in medical research, drug release, nanotechnology and new material research, cell culture. As well as ligand research, peptide synthesis support, grafted polymer compounds, new materials and polyethylene glycol modified functional coatings and other active compounds.
Basic Information
| Item | Description |
|---|---|
| Full Name | Thalidomide-O-PEG4-SPA (Thalidomide-O-PEG4-Succinimidyl Propionate) |
| CAS Number | 2411681-88-2 |
| Molecular Formula | C28H33N3O13 |
| Molecular Weight | 619.57 |
| Purity | ≥95% |
| Appearance | White solid or viscous liquid |
| Solubility | Soluble in water and most organic solvents |
| Storage Conditions | -5°C, dry, protected from light |
Detailed Information
| Item | Description |
|---|---|
| Structure | Thalidomide core linked to a PEG chain with four ethylene oxide units, terminated with a succinimidyl propionate (SPA) group |
| Reactivity | The succinimidyl propionate group reacts efficiently with primary amines to form stable amide bonds, making it suitable for bioconjugation applications. |
| Applications | – PROTAC Technology: Used as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.<br>- Medical Research: Applied in drug release, nanotechnology, and cell culture.<br>- Material Science: Used in the synthesis of functional coatings and polymers. |
| Advantages | – Combines the properties of Thalidomide, PEG, and a reactive succinimidyl propionate group.<br>- High biocompatibility and versatility in bioconjugation. |
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