distearoylphosphatidylethanolamine-PEG
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Category：Other Pharmaceutical Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog : HY-125924
CAS : 474922-26-4
| Aspect | Details |
|---|---|
| Structure | DSPE-PEG consists of distearoylphosphatidylethanolamine (DSPE) and polyethylene glycol (PEG). DSPE provides hydrophobicity and membrane affinity, while PEG offers hydrophilicity and biocompatibility. |
| Applications | Widely used in drug delivery systems, such as liposomes and nanoparticles. It enhances stability, prolongs circulation time, and reduces immunogenicity. |
| Functional Groups | Available in various forms with different functional groups (e.g., -NH2, -COOH, -Mal) for conjugation with drugs, targeting ligands, or imaging agents. |
| PEGylation Benefits | PEGylation improves water solubility, reduces protein adsorption, and enhances the stealth properties of drug carriers, allowing for longer circulation in the body. |
| Targeted Delivery | Can be conjugated with targeting molecules (e.g., transferrin) to achieve targeted drug delivery, improving therapeutic efficacy and reducing side effects. |
| Biomedical Imaging | Used in molecular imaging applications by conjugating with fluorescent dyes or radioactive labels to track drug carriers or diagnose diseases. |
| Stability and Compatibility | DSPE-PEG is stable in biological environments and compatible with various drug delivery formulations, making it suitable for both small and large molecule drug delivery. |
| Regulatory and Safety | Generally recognized as safe (GRAS) for use in pharmaceuticals and medical devices due to its biocompatibility and low toxicity |
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