Chemical Additives

Bromoacetyl Bromide

Chemical Formula: C₂H₂Br₂O
Structure: Acyl bromide with an ​acetyl group (-COCH₂-) where:

• A ​bromine atom is bonded to the carbonyl carbon.
• A ​bromo group (-Br) replaces one hydrogen on the adjacent methyl carbon.

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​Key Properties

• ​Physical State: Colorless to light yellow liquid with a ​pungent odor.
• ​Reactivity:
  • ​Moisture-sensitive: Reacts violently with water, releasing ​hydrogen bromide (HBr).
  • Highly reactive in ​acyl substitution reactions.
• ​Hazards: Corrosive, toxic, and flammable.

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​Applications

1. ​Organic Synthesis:
   • Introduces ​bromoacetyl groups into molecules for:
     • ​Pharmaceuticals (e.g., drug intermediates).
     • ​Agrochemicals (e.g., pesticide precursors).
     • ​Fine chemicals and ​dye/polymer intermediates.
2. ​Peptide Synthesis:
   • Activates carboxylic acids for peptide bond formation.
3. ​Bond Formation:
   • Facilitates ​carbon-carbon and ​carbon-heteroatom bond creation.

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​Safety Considerations ⚠️

• ​Handling:
  • Use ​PPE (gloves, goggles, lab coat) and work in a ​fume hood.
  • Avoid contact with skin, eyes, or inhalation.
• ​Storage:
  • Keep in a ​cool, dry, airtight container away from ​moisture and ​incompatible substances (e.g., bases, oxidizers).
• ​Disposal: Follow hazardous waste protocols due to ​HBr release and toxicity.

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Summary:
Bromoacetyl bromide’s ​high reactivity makes it indispensable for introducing bromoacetyl groups in chemical synthesis, but its ​corrosivity, toxicity, and moisture sensitivity demand stringent safety measures.

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