Zofenopril calcium salt CAS NO.81938-43-4
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017075
CAS NO.81938-43-4
Purity 96%
MDL NumberMFCD08704648
EINEC olecular formula 2(C22H22NO4S2).Ca
Molecular weight 897.1668
| Aspect | Details |
|---|---|
| Chemical Structure | – Molecular Formula: C₄₄H₄₄CaN₂O₈S₄<br>- Molecular Weight: 897.16 |
| Mechanism of Action | Zofenopril calcium is a prodrug ester analog of captopril. Its active metabolite, SQ 26,333, inhibits angiotensin-converting enzyme (ACE), leading to reduced formation of angiotensin II and lower blood pressure. |
| Clinical Uses | – Primarily used as an antihypertensive agent.<br>- Also has potential cardioprotective and anticonvulsant effects. |
| Pharmacokinetics | – Zofenopril calcium is rapidly absorbed and metabolized to its active form, SQ 26,333, which has a longer half-life compared to captopril.<br>- Excreted primarily in the urine. |
| Physical Properties | – Appearance: White to off-white powder.<br>- Solubility: Soluble in water and ethanol. |
| Storage Conditions | Store in a cool, dry place, protected from moisture and light. |
| Synonyms | – Zofenopril calcium<br>- SQ 26991<br>- Bifril<br>- Zoprace |
| Regulatory Status | – Approved for use as an antihypertensive agent in several countries. |
| Research Applications | – Investigated for its potential in cardiovascular protection and as an apoptosis inhibitor.<br>- Studied for its role in reducing cardiovascular events in clinical trials. |
Names and Identifiers
| Name | Zofenopril calcium |
| Synonyms | SQ26991 ZOPRACE Zoprace ZOFENOPRIL CALCIUM Zofenopril calcium ZOFENOPRIL CALCIUM SALT (4S)-1-[(2S)-3-(benzoylthio)-2-methyl-1-oxopropyl]-4-(phenylthio)-L-proline calcium salt (4S)-N-[3-(Benzoylsulfanyl)-2(S)-methylpropionyl]-4-(phenylsulfanyl)-L-proline calcium salt calcium bis[(2S,4S)-1-{(2S)-2-methyl-3-[(phenylcarbonyl)sulfanyl]propanoyl}-4-(phenylsulfanyl)pyrrolidine-2-carboxylate] |
| CAS | 81938-43-4 |
| InChI | InChI=1/2C22H23NO4S2.Ca/c2*1-15(14-28-22(27)16-8-4-2-5-9-16)20(24)23-13-18(12-19(23)21(25)26)29-17-10-6-3-7-11-17;/h2*2-11,15,18-19H,12-14H2,1H3,(H,25,26);/q;;+2/p-2/t2*15-,18+,19+;/m11./s1 |
81938-43-4 – Physico-chemical Properties
| Molecular Formula | C44H44CaN2O8S4 |
| Molar Mass | 897.16676 |
| Melting Point | >250°C |
| Boling Point | 646.3°C at 760 mmHg |
| Specific Rotation(α) | D23 -67.6° (c = 1 in methanol/HCl) |
| Flash Point | 344.7°C |
| Solubility | DMSO: >5mg/mL |
| Vapor Presure | 1.38E-17mmHg at 25°C |
| Appearance | powder |
| Color | white to off-white |
| Storage Condition | Inert atmosphere,2-8°C |
81938-43-4 – Risk and Safety
| Hazard Symbols | N – Dangerous for the environment |
| Risk Codes | 50/53 – Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. |
| Safety Description | S60 – This material and its container must be disposed of as hazardous waste. S61 – Avoid release to the environment. Refer to special instructions / safety data sheets. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 3 |
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