Nutritional Supplements

Zinc Gluconate: A Comprehensive Overview

Introduction

Zinc Gluconate (CAS No. 4468-02-4) is an organic zinc compound derived from gluconic acid, widely used as a dietary supplement and pharmaceutical agent. It offers high bioavailability and minimal gastric irritation, making it preferable to inorganic zinc sources.

Key Properties and Specifications

Parameter	Details
CAS Number	4468-02-4
Molecular Formula	C₁₂H₂₂O₁₄Zn
Molecular Weight	455.68 g/mol (anhydrous), 509.73 g/mol (trihydrate)
Appearance	White crystalline or granular powder, odorless, slightly astringent taste
Solubility	Freely soluble in water; insoluble in ethanol, chloroform, or ether
Melting Point	131°C
Boiling Point	673.6°C
pH of Solution	5.5–7.5 (10 g/L)
Storage Conditions	Tightly closed container, cool place

Applications and Uses

Nutritional Supplements

Zinc Deficiency: Treats growth retardation, anorexia, and skin disorders (e.g., acne) by restoring zinc levels.

Immune Support: Enhances immune function and accelerates wound healing.

Pediatric Use: Promotes physical and cognitive development in infants and children.

Food Fortification

Dairy Products: Added to milk, yogurt, and cheeses to improve nutritional value.

Infant Formulas: Ensures adequate zinc intake for optimal growth.

Beverages: Used in health drinks and energy supplements.

Pharmaceuticals

Antioxidant Therapy: Protects cells from oxidative stress.

Diabetes Management: Aids in insulin function and glucose metabolism.

Topical Preparations: Accelerates skin repair in ointments and creams.

Safety and Quality Control

Safety Profile	Quality Standards
Toxicity	LD50 (oral, rat) = 1290 mg/kg; low toxicity
Contraindications	Avoid overdosing; may interact with iron absorption
Purity	≥97.0% (anhydrous basis)
Heavy Metals	Arsenic ≤3 ppm, Cadmium ≤5 ppm, Lead ≤10 ppm

Market and Packaging

Zinc Gluconate is available in 25 kg bags under standards like USP, FCC, and GB. Its stability and neutral taste make it a versatile additive for global food and pharma industries.

Conclusion

Zinc Gluconate (CAS 4468-02-4) is a safe, effective, and bioavailable zinc source, essential for nutrition, healthcare, and wellness applications. Its compatibility with various delivery forms ensures broad utility across industries.