Xylometazoline HCl
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017986
CAS NO.1218-35-5
Purity 98%
MDL NumberMFCD00238707
Molecular FormulaC16H24N2.HCl
Molecular Weight280.8361
Melting point: >300°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C16H25ClN2<br> Molecular weight: 280.84 g/mol |
| Physical Properties | Appearance: White to off-white solid<br> Melting point: 131–133°C |
| Mechanism of Action | Acts as an α-adrenergic receptor agonist, primarily targeting α1A and α2B receptors. It constricts nasal blood vessels, reducing swelling and congestion. |
| Therapeutic Uses | Nasal Congestion: Used to relieve nasal congestion caused by the common cold, sinusitis, allergic rhinitis, and other respiratory conditions.<br> Research: Investigated for its effects on nasal mucosa and potential use in treating sinusitis. |
| Formulations | Available as a nasal spray (0.05% concentration) for topical use. |
| Dosage | Adults and children over 12 years: 1–2 sprays per nostril every 8–10 hours.<br> Children aged 6–12: 1 spray per nostril every 8–10 hours. |
| Storage Conditions | Store at room temperature, protect from moisture and heat. |
| Safety Information | Side Effects: Temporary burning, stinging, dryness in the nose, runny nose, and sneezing.<br> Contraindications: Avoid in patients with narrow-angle glaucoma, severe cardiovascular disease, or those taking MAOIs.<br> Pregnancy and Lactation: Use with caution; consult a doctor.<br> Rebound Congestion: Prolonged use (more than 3 days) can lead to worsening of nasal congestion. |
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