FAQ

4-Nitroimidazole (CAS No. 3034-38-6) is a valuable organic compound with diverse applications across pharmaceuticals, chemical synthesis, and research.

1. Pharmaceutical Intermediate:
   • Serves as a critical precursor in the synthesis of antiprotozoal and antimicrobial drugs, such as ronidazole, which is effective against protozoal infections (e.g., Tritrichomonas foetus in cats) and used in veterinary medicine.
   • Contributes to the development of nitroimidazole-based antibiotics targeting anaerobic bacteria and certain parasites.
2. Organic Synthesis:
   • Acts as a versatile building block for constructing heterocyclic compounds, facilitating the synthesis of functionalized imidazoles with tailored properties for pharmaceutical, agrochemical, or material science applications.
   • Utilized in the preparation of 1-methyl-2,4,5-trinitroimidazole, a compound with potential explosive or energetic material applications.
3. Research and Development:
   • Employed in academic and industrial research to explore the catalytic efficiency of heterocyclic compounds in peroxyoxalate chemiluminescence reactions, enabling advancements in analytical chemistry and biotechnology.
   • Serves as a model compound for studying the reactivity of nitroimidazoles, including their reduction chemistry (e.g., conversion to aminoimidazoles) and participation in nucleophilic substitution reactions.

Physicochemical Properties:

• Molecular Formula: C₃H₃N₃O₂
• Molecular Weight: 113.07 g/mol
• Melting Point: 303°C (decomposes)
• Appearance: White to pale yellow crystalline powder
• Solubility: Sparingly soluble in water; soluble in polar organic solvents (e.g., alcohols)

Safety and Handling:

• Toxicity: Classified as harmful if swallowed, inhaled, or in contact with skin; may cause irritation or sensitization.
• Handling Precautions: Requires protective equipment (gloves, goggles, lab coat) and proper ventilation to minimize exposure risks.
• Storage: Store in a cool, dry, and well-ventilated area, away from incompatible materials (e.g., strong oxidizing agents).