FAQ

2-Bromo-4-fluoroaniline (CAS No.: 1003-98-1)

1. Basic Information

• Chemical Name: 2-Bromo-4-fluoroaniline
• Synonyms: 2-Bromo-4-fluoro-phenylamine, 4-Fluoro-2-bromoaniline
• CAS Number: 1003-98-1
• Molecular Formula: C₆H₅BrFN
• Molecular Weight: 190.01 g/mol
• Physical State: Transparent yellow-to-brown liquid
• Melting Point: 41 °C
• Boiling Point: 221 °C (760 mmHg)
• Density: 1.67 g/cm³ (25 °C)
• Flash Point: 104.4 °C
• Solubility: Partially miscible in water; soluble in organic solvents.

2. Chemical Properties

• Reactivity: Contains a bromine atom and a fluorine atom on the benzene ring, making it a versatile intermediate for nucleophilic substitution and cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig).
• Stability: Stable under normal conditions but should be protected from strong oxidizing agents, moisture, and light.

3. Applications

• Pharmaceuticals:
  • Key intermediate in the synthesis of active pharmaceutical ingredients (APIs), including anticancer, antiviral, and antimicrobial agents.
  • Used in the development of drugs targeting specific enzymes or receptors.
• Agrochemicals:
  • Precursor for herbicides, insecticides, and fungicides.
• Dyes and Pigments:
  • Employed in the synthesis of azo dyes and fluorescent pigments.
• Materials Science:
  • Utilized in the preparation of polymers, liquid crystals, and advanced functional materials.

4. Safety and Handling

• Hazards:
  • Toxic: Harmful if swallowed, inhaled, or absorbed through the skin.
  • Irritant: Causes skin and eye irritation; may cause respiratory tract irritation.
• GHS Classification:
  • Skin Corrosion/Irritation (Category 2)
  • Eye Damage/Irritation (Category 2A)
  • Specific Target Organ Toxicity (Single Exposure, Category 3)
• Precautionary Measures:
  • Wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat.
  • Avoid inhalation of vapors or dust; ensure adequate ventilation.
  • Store in a cool, dry, and well-ventilated area, away from incompatible materials (e.g., strong oxidizers).

5. Environmental and Health Impact

• Environmental Fate: Slightly harmful to aquatic life; avoid release into the environment.
• Health Effects:
  • Acute Exposure: May cause irritation, nausea, or dizziness.
  • Chronic Exposure: Potential for systemic toxicity; seek medical attention if exposed.

6. Regulatory and Compliance

• Transportation: Classified as a hazardous material (UN2810, Class 6.1, Packing Group III).
• Waste Disposal: Dispose of in accordance with local regulations for hazardous waste.

7. Synthesis and Availability

• Synthesis: Typically prepared via aromatic nucleophilic substitution or cross-coupling reactions starting from fluorinated or brominated anilines.
• Suppliers: Available from chemical suppliers such as Sigma-Aldrich, TCI Chemicals, and Alfa Aesar.