FAQ

3,5-Difluorochlorobenzene (CAS No. 1435-43-4) is a versatile compound with significant applications in pharmaceuticals, agrochemicals, and organic synthesis.

1. Pharmaceutical Intermediate

• Serves as a critical building block for the synthesis of drug molecules, hormones, and bioactive compounds. Its fluorinated and chlorinated aromatic structure provides unique reactivity and pharmacokinetic properties, making it valuable in drug discovery and development.

2. Agrochemical Intermediate

• Utilized in the production of pesticides and herbicides, where its fluorine and chlorine substituents enhance the stability and efficacy of agrochemical formulations.

3. Organic Synthesis

• Acts as a reagent or intermediate in various organic transformations, including:
  • C-F/C-Cl Bond Activation: Facilitates the conversion of chlorine to boronic acid derivatives or boronic esters under palladium catalysis.
  • Cross-Coupling Reactions: Enables the formation of C-N bonds (e.g., amination) to generate deuterated or substituted amine derivatives.
  • Synthetic Pathways: Serves as a starting material for the synthesis of complex aromatic compounds used in materials science and specialty chemicals.

4. Reaction Solvent

• Occasionally employed as a solvent in organic reactions due to its compatibility with polar and non-polar systems, though this is not its primary application.

5. Synthetic Examples

• 3-Chloro-5-fluoro-diphenylamine: Synthesized via palladium-catalyzed amination of 3,5-difluorochlorobenzene with aniline.
• Boronic Acid Derivatives: Prepared through transition metal-mediated reactions, enabling further functionalization.

Safety and Handling

• Classified as an irritant (Xi) and flammable (F), it requires careful storage in sealed containers at room temperature, away from strong oxidizing agents and moisture. Proper ventilation and protective equipment are essential during handling.

Market Availability

• Commercially available from suppliers like Sigma-Aldrich, TCI, and Alfa Aesar with purities ranging from 97% to 99.5%, catering to research and industrial needs.