Vorinostat
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80071770
CAS NO.149647-78-9
Purity 98%
MDL NumberMFCD00945317
Molecular Formula C14H20N2O3
Molecular Weight 264.323
Melting point: 162~168°C
| Item | Information |
|---|---|
| Mechanism of Action | Vorinostat is a histone deacetylase (HDAC) inhibitor that targets Class I (HDAC1, HDAC2, HDAC3) and Class II (HDAC6) enzymes. It inhibits the removal of acetyl groups from histones, leading to the accumulation of acetylated histones and transcriptional activation. This can induce cell cycle arrest, apoptosis, and inhibition of angiogenesis. |
| Indications | FDA-approved for the treatment of cutaneous T-cell lymphoma (CTCL) in patients who have not responded to other therapies. It is also being investigated for other cancers, including prostate cancer, leukemia, breast cancer, glioma, and lung cancer. |
| Dosage Forms | Available as oral capsules (100 mg) and intravenous formulations. |
| Recommended Dosing | The standard oral dose is 400 mg once daily. If adverse effects are intolerable, the dose may be reduced to 300 mg once daily. |
| Pharmacokinetics | Vorinostat has a half-life of approximately 60-100 minutes. It is metabolized via glucuronidation and excreted in urine. |
| Common Side Effects | Fatigue, nausea, vomiting, diarrhea, anorexia, thrombocytopenia, and neutropenia. |
| Storage Conditions | Store at room temperature, protected from moisture. |
| Special Precautions | Monitor for hematologic toxicity, especially with intravenous administration. Patients should be evaluated for other skin-directed therapies before starting Vorinostat. |
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