Volasertib (BI 6727)
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID92519
CAS NO.755038-65-4
Purity 95+%
MDL NumberMFCD20926414
Molecular Formula C34H50N8O3
Molecular Weight 618.813
| Category | Content |
|---|---|
| Generic Name | Volasertib (BI 6727) |
| Chemical Formula | C25H15ClF2N4O2 |
| CAS Number | 755038-65-4 |
| Mechanism of Action | Volasertib is a potent and selective inhibitor of Polo-like kinase 1 (Plk1), with an IC50 of 0.87 nM. It induces mitotic arrest and apoptosis in cancer cells by disrupting the mitotic spindle assembly. |
| Indications | – Investigated for the treatment of acute myeloid leukemia (AML) in patients who are not eligible for intensive remission induction therapy.<br>- Also studied in various solid tumors and other hematologic malignancies. |
| Clinical Trials | – Phase II: Demonstrated higher response rates and improved event-free survival when combined with low-dose cytarabine (LDAC) compared to LDAC alone in AML patients.<br>- Phase III: Ongoing study (POLO-AML-2) to further evaluate the efficacy of volasertib + LDAC in AML patients. |
| Pharmacokinetics | – High volume of distribution, indicating good tissue penetration.<br>- Long terminal half-life. |
| Side Effects | – Common: Nausea, vomiting, fatigue, neutropenia.<br>- Serious: Myelosuppression, infections. |
| Developer | Boehringer Ingelheim |
| Approval Status | – Granted Breakthrough Therapy designation by the FDA for AML.<br>- Currently in Phase III clinical development |
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