Vitamin K3 CAS 58-27-5
Vitamins 2025-03-11
Product name:Vitamin K3
Molecular Formula:C11H8O2
Molecular Weight:172.2
CAS No.:58-27-5
Description
Menadione is a pale-yellow, crystalline powder. It is practically insoluble in water, freely soluble in toluene, sparingly soluble in alcohol and in methanol. It is unstable in light.
Application
Vitamin K3 is a procoagulant that can be used to treat bleeding disorders caused by vitamin K deficiency, such as neonatal hemorrhage, vitamin K deficiency caused by intestinal malabsorption, and low prothrombinemia.
Specification
| Category | Parameters |
|---|---|
| Chemical Identity | |
| – IUPAC Name | 2-methyl-1.4-naphthoquinone. |
| – CAS Number | 58-27-5. |
| – Molecular Formula | C₁₁H₈O₂. |
| – Molecular Weight | 172.18 g/mol. |
| Physical Properties | |
| – Appearance | Bright yellow to orange crystalline powder. |
| – Odor | Slight characteristic odor. |
| – Solubility | Soluble in water (1.2 g/100 mL at 25°C); slightly soluble in ethanol. |
| – Melting Point | 106–110°C. |
| Quality Standards | |
| – Assay (USP/EP) | ≥98% (HPLC). |
| – Loss on Drying | ≤1.0%. |
| – Residual Solvents | Meets ICH Q3C guidelines (e.g., methanol ≤3000 ppm). |
| – Heavy Metals | ≤10 ppm. |
| – Arsenic | ≤1 ppm. |
| – Microbiological | Total aerobic count ≤1000 CFU/g; absent E. coli, Salmonella. |
| Applications | |
| – Animal Feed | Poultry, swine, aquaculture (growth promotion, bone health). |
| – Pharmaceuticals | Topical ointments for wound healing; anticoagulant reversal (historical use). |
| – Cosmetics | Skincare formulations (antioxidant, anti-inflammatory). |
| Storage | Cool (2–8°C), dry, airtight container; protect from light. Shelf life: 24 months. |
| Regulatory Status | Listed in USP/NF, EP, JP; approved as feed additive (E.U., FDA). |
