Vitamins

Molecular Formula: C31H46O2

Molecular Weight: 450.7

CAS No.: 84-80-0

Product name:Vitamin K1 (Phytomenadione)

It is an oily liquid or solid, insoluble in water, soluble in organic solvents such as grease and ether, with stable chemical properties, heat and acid resistance, but easy to be decomposed by alkali and ultraviolet light. Vitamin K, which is rarely needed by the human body and is easily lacking by newborns, is an important vitamin to promote normal blood coagulation and bone growth of the Chemicalbook. Dark green vegetables and yogurt are easy to obtain vitamin K supplements in daily diet. The human body needs very little vitamin K, but it can maintain the normal coagulation of blood function, reduce massive bleeding in physiological period, and prevent internal bleeding and hemorrhoids.

Description

It is a clear, intense yellow, viscous, oily liquid. It is practically insoluble in water, sparingly soluble in ethanol (96 per cent), miscible with fatty oils. It decomposes on exposure to actinic light.

Application

It is used as a food fortifier and can be used in infant foods. As a vitamin drug, it can be used for vitamin K1 deficiency, thrombin hypoxia, prevention and treatment of neonatal natural hemorrhagic disease, etc.

Specification

Category	Parameters
Chemical Identity
– IUPAC Name	2-methyl-3-phytyl-1.4-naphthoquinone.
– CAS Number	84-80-0.
– Molecular Formula	C₃₁H₄₀O₂.
– Molecular Weight	452.65 g/mol.
Physical Properties
– Appearance	Yellow to orange crystalline powder.
– Odor	Characteristic.
– Solubility	Insoluble in water; soluble in fats, alcohols, chloroform.
– Melting Point	42–44°C.
Quality Standards
– Assay (USP/EP)	≥97% (HPLC).
– Loss on Drying	≤0.5%.
– Residual Solvents	Meets ICH Q3C guidelines (e.g., hexane ≤290 ppm).
– Heavy Metals	≤10 ppm.
– Arsenic	≤1 ppm.
– Microbiological	Total aerobic count ≤1000 CFU/g; absent E. coli, Salmonella.
Applications
– Food Fortification	Dairy products, margarine.
– Dietary Supplements	Softgels, multivitamins.
– Pharmaceuticals	Prothrombin deficiency treatment; anticoagulant reversal (e.g., warfarin).
– Cosmetics	Anti-aging creams (vitamin K-based formulations).
Storage	Cool (2–8°C), dry, airtight container; protect from light and moisture. Shelf life: 24 months.
Regulatory Status	GRAS (FDA); USP/NF, EP, JP monographs; listed in EU Novel Food Catalogue.

 

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