Vilanterol
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID92517
CAS NO.503068-34-6
Purity 97%
MDL NumberMFCD18782703
Molecular FormulaC24H33Cl2NO5
Molecular Weight486.43
| Category | Content |
|---|---|
| Generic Name | Vilanterol |
| Chemical Formula | C24H33Cl2NO5 |
| CAS Number | 503068-34-6 |
| Mechanism of Action | Vilanterol is a selective long-acting beta2-adrenergic agonist. It stimulates intracellular adenylyl cyclase, which converts ATP to cAMP, leading to relaxation of bronchial smooth muscle and inhibition of hypersensitivity mediator release from mast cells. |
| Indications | – Used in combination with fluticasone furoate (Breo Ellipta) for long-term, once-daily maintenance treatment of airflow obstruction in COPD and asthma.<br>- Also used with umeclidinium bromide (Anoro Ellipta) and both fluticasone furoate and umeclidinium (Trelegy Ellipta) for COPD and asthma maintenance. |
| Dosage Forms | Inhalation powder (e.g., 25 mcg, 50 mcg, 100 mcg, 200 mcg) in combination products. |
| Administration | Inhaled once daily. Patients should rinse their mouth with water after use to reduce the risk of oral thrush. |
| Pharmacokinetics | – Absorption: Primarily absorbed from the lung after inhalation, with a Cmax at 5-15 minutes.<br>- Half-life: 11 hours (effective half-life), 16-21.3 hours (plasma elimination half-life).<br>- Metabolism: Primarily via CYP3A4. |
| Side Effects | – Common: Sore throat, common cold symptoms.<br>- Serious: Increased risk of pneumonia, low potassium levels, slow growth in children, weakened bones. |
| Precautions | – Not for use as a rescue inhaler during sudden asthma attacks.<br>- Monitor for infections, blood sugar levels, and bone density.<br>- Avoid use in patients allergic to any components. |
| Storage | Store at room temperature (68-77°F; 20-25°C), protect from moisture. |
| Developer | GlaxoSmithKline (GSK) |
| Approval Date | FDA approval in 2013. |
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