Viaminate CAS NO.53839-71-7
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017133
CAS NO.53839-71-7
Purity 95%
MDL NumberMFCD01684778
EINEC Molecular Formula C29H37NO3
Molecular Weight 447.609
Melting point: 177~182°C
| Aspect | Details |
|---|---|
| Chemical Structure | Viaminate is a derivative of retinoic acid, specifically an amide compound formed by tretinoin and ethyl p-aminobenzoate. Its molecular formula is C₂₉H₃₇NO₃ with a molecular weight of 447.61 g/mol. |
| Mechanism of Action | It regulates epithelial cell differentiation and proliferation, inhibits keratinization, reduces sebum secretion, and has immunological and anti-inflammatory effects. It also inhibits the TLR2/NF-κB and MAPK pathways, which are involved in acne pathogenesis. |
| Clinical Uses | Viaminate is primarily used for the treatment of severe acne and other keratinization disorders. It is also being studied for its potential in regulating fatty acid metabolism and cellular keratinization pathways. |
| Pharmacokinetics | Viaminate has therapeutic effects similar to other retinoids but with fewer adverse effects. Its exact pharmacokinetic properties are not fully detailed in the available literature. |
| Storage Conditions | Store at room temperature and protect from light. |
| Side Effects | While generally well-tolerated, it may cause liver dysfunction in rare cases. |
| Research Findings | Recent studies have shown that viaminate can improve acne symptoms by inhibiting the proliferation and inflammatory response of keratinocytes, mediated through the deactivation of TLR2 and its downstream pathways. |
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