Vecuromium bromide CAS NO.50700-72-6
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017787
CAS NO.50700-72-6
Purity 98+%
MDL NumberMFCD00867762
Molecular Formula C34H57N2O4.Br
Molecular Weight 637.7314
Melting point: 238~240°C
| Aspect | Details |
|---|---|
| Mechanism of Action | Vecuronium bromide is a non-depolarizing neuromuscular blocking agent that competitively inhibits the action of acetylcholine at the nicotinic acetylcholine receptors (nAChRs) on skeletal muscles. It provides muscle relaxation by blocking nerve impulses to the muscles. |
| Pharmacokinetics | – Bioavailability: 100% (IV).<br>- Metabolism: Approximately 30% is metabolized in the liver.<br>- Onset of Action: Less than 1 minute.<br>- Elimination Half-Life: 51–80 minutes (longer with kidney failure).<br>- Duration of Action: 15–30 minutes.<br>- Excretion: 40–75% via feces and 30% via kidneys as unchanged drug and metabolites. |
| Indications | Used as an adjunct to general anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation. It is also used to facilitate endotracheal intubation. |
| Administration | Administered intravenously. The effects are maximal at about 4 minutes and last for up to an hour. |
| Adverse Effects | May include low blood pressure and prolonged paralysis. Allergic reactions are rare. |
| Reversal Agents | The effects of vecuronium can be reversed using sugammadex, which encapsulates vecuronium and prevents it from binding to receptors. Neostigmine or other cholinesterase inhibitors can also be used, though they are less effective than sugammadex. |
| Storage Conditions | Store at 4°C, sealed and away from moisture. |
| Legal and Regulatory | Vecuronium bromide is classified as a prescription-only medicine in the US. It is also listed on the World Health Organization’s List of Essential Medicines. |
| Other Uses | Vecuronium bromide has been used in lethal injection protocols in the US as part of a drug cocktail to paralyze the prisoner and stop breathing. |
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