Active Pharmaceutical Ingredients

Catalog ID80071769

CAS NO.443913-73-3

Purity 95% MDL NumberMFCD07772346

Molecular FormulaC22H24BrFN4O2

Molecular Weight475.36

Melting point: 240 – 243°C

Item	Information
Mechanism of Action	Vandetanib is a tyrosine kinase inhibitor that targets the epidermal growth factor receptor (EGFR), RET, and VEGFR families. It inhibits tumor growth and angiogenesis by blocking these receptors.
Indications	– Treatment of locally advanced or metastatic medullary thyroid cancer (MTC) in adults.<br>- Investigational use in non-small cell lung cancer (NSCLC) and other solid tumors.
Dosage Forms	Available as oral tablets.
Common Side Effects	Diarrhea, rash, nausea, hypertension, decreased appetite, fatigue, headache, vomiting, and blurred vision.
Serious Side Effects	QT prolongation, interstitial lung disease, heart failure, bleeding, stroke, reversible posterior leukoencephalopathy syndrome (RPLS), slow wound healing.
Special Precautions	– Regular monitoring of heart function (EKG), blood pressure, and thyroid function.<br>- Avoid sun exposure and use sunscreen to reduce risk of skin reactions.<br>- Women and men of reproductive potential should use effective contraception during treatment and for at least 4 months after the last dose.<br>- Avoid concomitant use with other drugs that may prolong QT interval.
Storage Conditions	Store at room temperature, protected from light and moisture

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