Urapidil CAS NO.34661-75-1
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017865
CAS NO.34661-75-1
Purity 96%
MDL NumberMFCD00133908
Molecular Formula C20H29N5O3
Molecular Weight 387.476
Melting point: 156~158°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C20H29N5O3<br> Molecular weight: 387.48 g/mol |
| Mechanism of Action | Urapidil is a selective α1-adrenoceptor antagonist with a dual mechanism of action. It lowers blood pressure by blocking peripheral α1-adrenoceptors, leading to vasodilation. Additionally, it acts centrally by stimulating serotonin 5-HT1A receptors, reducing sympathetic activity. |
| Therapeutic Uses | Hypertension: Used for treating hypertension, including hypertensive crises, perioperative hypertension, and pre-eclampsia.<br> Acute Heart Failure: Effective in elderly hypertensive patients with acute heart failure. |
| Pharmacokinetics | Absorption: Well-absorbed orally, with peak plasma concentrations reached within 0.5–1 hour.<br> Distribution: Plasma protein binding rate is about 80%.<br> Metabolism: Metabolized primarily in the liver.<br> Excretion: 50%–70% excreted in urine, with a terminal half-life of 2.7 hours. |
| Formulations | Available as tablets and intravenous injections. |
| Storage Conditions | Store at room temperature, protected from light and moisture. |
| Safety Information | Side Effects: Dizziness, nausea, headache, fatigue, palpitations.<br> Contraindications: Not recommended for patients with aortic stenosis or arteriovenous shunts.<br> Special Populations: Use with caution in elderly patients due to prolonged elimination half-life. |
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