Tris(hydroxymethyl)aminomethane CAS Number: 77-86-1
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Category：Pharmaceutical Materials | Brand：MT
Introduction
CAS Number: 77-86-1
Molecular Formula: C4H11NO3
Molecular Weight: 121.14
Appearance: White crystalline powder
Melting Point: 168-172°C pH Range: 7-9 (aqueous solution)
Usage: Used as a buffer in biochemical and molecular biology experiments.
Tris(hydroxymethyl)aminomethane, commonly known as Tris, is an organic compound with the CAS Number 77-86-1. It is a white crystalline powder that is highly soluble in water and ethanol. Tris is widely used as a buffering agent in biochemical and molecular biology experiments due to its ability to maintain a stable pH range of 7.0 to 9.2. It is also used in electrophoresis, as a solvent for nucleic acids and proteins, and as an intermediate in the preparation of surfactants and other chemicals. However, Tris is a corrosive compound and can cause skin and eye irritation, so it should be handled with appropriate safety measures.
| Property | Value |
|---|---|
| CAS Number | 77-86-1 |
| Physical Properties | – |
| Molecular Formula | C4H11NO3 |
| Molecular Weight | 121.14 g/mol |
| Appearance | White crystalline powder |
| Melting Point | 171-172 °C |
| Boiling Point | 219-220 °C (10 mmHg) |
| Density | 1.3530 g/mL |
| Chemical Properties | – |
| Solubility | Soluble in water, ethanol; slightly soluble in acetic ester, benzene; insoluble in ether, carbon tetrachloride |
| pH Range (Buffering) | 7.0-9.2 |
| pKa | 8.1 at 20 °C; 7.82 at 37 °C |
| Reactivity | Corrosive to copper and aluminum; can cause skin and eye irritation |
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