Trioxsalen
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID 80071768
CAS NO.3902-71-4
Purity 98%
MDL NumberMFCD00005010
Molecular Formula C14H12O3
Molecular Weight 228.246
| Item | Information |
|---|---|
| Mechanism of Action | Trioxsalen is a psoralen derivative that acts as a photochemical DNA crosslinker. It becomes active only after photoactivation with near-ultraviolet light (UVA), causing DNA crosslinking and potentially leading to cell death. |
| Uses | – Used in combination with UVA light (PUVA therapy) to treat vitiligo, a condition characterized by loss of skin color.<br>- Also used to increase skin tolerance to sunlight.<br>- Investigated for treating hand eczema and other skin conditions. |
| Side Effects | – Common: Skin redness, itching, swelling, blisters, nausea, dizziness.<br>- Severe: Increased risk of sunburn, skin damage, premature skin aging, cataracts.<br>- Other: Mental depression, nervousness, trouble sleeping. |
| Storage Conditions | Store at -20°C for 3 years (powder form); at 4°C for 2 years (powder); in solvent at -80°C for 2 years. |
| Precautions | – Avoid sun exposure for at least 8 hours after treatment.<br>- Use protective clothing and sunscreen with SPF 15 or higher.<br>- Protect eyes with wraparound sunglasses that block UV light for 24 hours after treatment.<br>- Avoid certain foods (e.g., limes, figs, parsley) that increase photosensitivity. |
| Contraindications | – Not recommended for patients with porphyria or acute autoimmune diseases.<br>- Avoid in pregnant or breastfeeding women due to lack of safety data.<br>- Do not use if allergic to trioxsalen or its components. |
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