Active Pharmaceutical Ingredients

Molecular Formula: C32H34N4O15S4Na4

Molecular Weight:934.84

CAS No.:738-37-2

Description

Trimethoprim Water Soluble 30% is white, off-white or light yellow powder, odorless and bitter. This product is soluble in water and slightly soluble in ethanol.

Application

This product is an antibacterial synergist, used alone for respiratory infections, urinary tract infections, intestinal infections and other diseases. As an antibacterial synergist, it can also treat poultry bacterial infections and coccidiosis. It can be mixed with basic antibacterial drugs such as sulfa drugs to make stable powders and finished products such as water needles, which can increase the antibacterial effect of sulfa drugs by several to dozens of times.

Packing

25Kg per fibre drum

Storage

Under normal room temperature, away from the direct sunlight.

Supply Availability

Prompt

Item	Content
Introduction	Trimethoprim is a widely used antibiotic, often combined with sulfamethoxazole to treat bacterial infections. It is also available as a water-soluble formulation for specific applications.
Chemical Information	– Molecular Formula: C₁₄H₁₈N₄O₃<br>- Molecular Weight: 290.31
Appearance	White to cream, crystalline powder.
Solubility	– Water Solubility: 400 mg/L at 25°C.<br>- Alcohol Solubility: Slightly soluble.
Melting Point	199-203°C.
pKa	7.12.
LogP	0.91.
Stability	Trimethoprim is more stable in acidic conditions. Its solubility decreases in alkaline solutions.
Mechanism of Action	Trimethoprim is a reversible inhibitor of dihydrofolate reductase, an enzyme essential for bacterial nucleic acid and protein synthesis. It selectively targets bacterial enzymes, preventing bacterial growth.
Applications	– Antibiotic Therapy: Often combined with sulfamethoxazole to treat urinary tract infections, respiratory infections, and other bacterial infections.<br>- Water-Soluble Formulation: Used in veterinary medicine and for specific pharmaceutical preparations requiring enhanced solubility.
Storage Conditions	Store in a cool, dry place, protected from light and moisture.
Environmental Impact	Trimethoprim can be released into the environment through waste streams. It has low potential for bioconcentration in aquatic organisms and is slowly biodegradable.

 

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