Trimebutine CAS NO.39133-31-8
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80017769
CAS NO.39133-31-8
Purity 98%
MDL NumberMFCD00133873
Molecular FormulaC22H29NO5
Molecular Weight387.4694
Melting point: 78~80°C
| Aspect | Details |
|---|---|
| Mechanism of Action | Trimebutine is a spasmolytic agent that acts directly on smooth muscle to modulate gastrointestinal (GI) motility. It has a dual function: at lower concentrations, it stimulates contractions by inhibiting outward potassium currents, while at higher concentrations, it inhibits contractions by blocking L-type calcium channels. Additionally, it acts as a weak agonist at mu-opioid receptors, providing local anesthetic effects. |
| Pharmacokinetics | – Absorption: Rapidly absorbed after oral administration, with peak plasma concentration reached within 1 hour.<br>- Distribution: Accumulates primarily in the stomach and intestinal walls.<br>- Metabolism: Undergoes extensive hepatic first-pass metabolism, with active metabolites such as N-monodesmethyltrimebutine.<br>- Elimination: Predominantly excreted by the kidneys as metabolites; less than 2.4% of the drug is excreted unchanged in urine. |
| Indications | Used to treat functional gastrointestinal disorders such as irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), and functional dyspepsia. |
| Adverse Effects | Generally well-tolerated, but may cause dizziness, somnolence, or gastrointestinal discomfort. |
| Storage Conditions | Store at room temperature, protected from moisture. |
| Special Considerations | – Pregnancy and Lactation: Use with caution; fetal transfer is reported to be low.<br>- Antimicrobial Activity: Preliminary studies suggest trimebutine has in vitro antimicrobial activity against certain bacteria, potentially offering additional therapeutic benefits in post-infectious functional gastrointestinal disorders |
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