Trifluoroacetyl Chloride CAS No. 354-32-5
Agrochemicals 2025-03-02
Trifluoroacetyl Chloride
CAS No.: 354-32-5 | EC No.: 206-556-2 | UN No.: 3057
1. Chemical Identification
| Property | Specification |
|---|---|
| IUPAC Name | 2,2,2-Trifluoroacetyl chloride |
| Molecular Formula | C₂ClF₃O |
| Molecular Weight | 132.47 g/mol |
| Appearance | Colorless gas |
| Density | 1.335 g/cm³ (liquid at 20°C) |
| Melting Point | -146°C |
| Boiling Point | -27°C |
| Refractive Index | 1.309 |
| Flash Point | -58.1±25.9°C |
Synonyms:
TFAC, Perfluoroacetyl chloride
2. Key Applications
Agrochemical Synthesis
- Fluorinated Pesticides: Key intermediate for modern crop protection agents
Pharmaceutical Manufacturing
- Active Ingredients: Production of fluorinated drugs
- Peptide Synthesis: Protecting group reagent
Specialty Chemicals
- Fluorinated organic intermediates
- Fine chemical production
3. Product Advantages
✔ High Reactivity – Excellent acylating agent
✔ Fluorine Synergy – Enhances bioactivity of end products
✔ Process Efficiency – Enables clean reaction pathways
4. Physical & Chemical Properties
- Solubility:
- Reacts violently with water/alcohols
- Soluble in inert organic solvents
- Stability:
- Moisture-sensitive – store under dry inert gas
- Corrosive to most metals
5. Handling & Storage
| Parameter | Requirement |
|---|---|
| Storage Temp | -20°C (cylinder) |
| Packaging | 10kg stainless steel cylinders |
| Special Notes | Use nickel/alloy equipment |
6. Safety Information
Danger!
- H314: Causes severe skin burns and eye damage
- H330: Fatal if inhaled
- H331: Toxic if inhaled
Protective Measures:
- P260: Do not breathe gas
- P280: Wear face shield/acid-resistant gloves
- P310: Immediate medical attention required
7. Quality Specifications
- Purity: ≥99% (GC)
- Acid Content: ≤0.1%
- Non-volatile Matter: ≤0.01%
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