Triethyl orthoformate
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Category：Pharmaceutical Materials Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS Number: 122-51-0
Molecular Formula: C7H16O3
Molecular Weight: 148.2
Appearance: Colorless liquid
Usage: Used as a pharmaceutical intermediate and a water scavenger in polyurethane systems.
Flash Point: 38°C (100.4°F)
| Aspect | Details |
|---|---|
| Name | Triethyl Orthoformate |
| Synonyms | Ethyl Orthoformate; Triethoxymethane; 1.1.1-Triethoxymethane |
| CAS Number | 122-51-0 |
| Chemical Formula | C₇H₁₆O₃ |
| Molecular Weight | 148.20 g/mol |
| Physical Properties | – Appearance: Colorless liquid with a pungent odor |
| – Boiling Point: 146°C | |
| – Density: 0.891 g/mL (25°C) | |
| – Solubility: Miscible with ethanol, ether; slightly soluble in water | |
| Synthetic Routes | 1. Ethanol-Sodium Chloride Method: Reaction of chloroform with sodium ethoxide. |
| 2. Benzoyl Chloride Method: Reaction of benzoyl chloride with formamide and ethanol. | |
| Applications | – Pharmaceuticals: Intermediate in synthesizing chloroquine, pyrimethamine, and fluoroquinolones. |
| – Pesticides: Precursor for acaricides (e.g., amitraz) and herbicides. | |
| – Dyes: Used in synthesizing cyanine and phthalocyanine dyes. | |
| Safety Precautions | – Handling: Use in a fume hood; avoid contact with moisture and strong oxidizers. |
| Storage: Keep in airtight containers, away from heat and ignition sources. |
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