Triethyl orthoformate
Pharmaceutical Materials 2025-03-02
CAS Number: 122-51-0
Molecular Formula: C7H16O3
Molecular Weight: 148.2
Appearance: Colorless liquid
Usage: Used as a pharmaceutical intermediate and a water scavenger in polyurethane systems.
Flash Point: 38°C (100.4°F)
| Aspect | Details |
|---|---|
| Name | Triethyl Orthoformate |
| Synonyms | Ethyl Orthoformate; Triethoxymethane; 1.1.1-Triethoxymethane |
| CAS Number | 122-51-0 |
| Chemical Formula | C₇H₁₆O₃ |
| Molecular Weight | 148.20 g/mol |
| Physical Properties | – Appearance: Colorless liquid with a pungent odor |
| – Boiling Point: 146°C | |
| – Density: 0.891 g/mL (25°C) | |
| – Solubility: Miscible with ethanol, ether; slightly soluble in water | |
| Synthetic Routes | 1. Ethanol-Sodium Chloride Method: Reaction of chloroform with sodium ethoxide. |
| 2. Benzoyl Chloride Method: Reaction of benzoyl chloride with formamide and ethanol. | |
| Applications | – Pharmaceuticals: Intermediate in synthesizing chloroquine, pyrimethamine, and fluoroquinolones. |
| – Pesticides: Precursor for acaricides (e.g., amitraz) and herbicides. | |
| – Dyes: Used in synthesizing cyanine and phthalocyanine dyes. | |
| Safety Precautions | – Handling: Use in a fume hood; avoid contact with moisture and strong oxidizers. |
| Storage: Keep in airtight containers, away from heat and ignition sources. |
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
