Trans-4-Aminocyclohexanol
Pharmaceutical Materials 2025-03-02
CAS Number: 27489-62-9
Molecular Formula: C6H13NO
Molecular Weight: 115.174 g/mol
Appearance: White to pale yellow crystalline powder
Melting Point: 108-113°C
Boiling Point: 201.1°C at 760 mmHg
Usage: Used as an intermediate in organic synthesis, particularly in the synthesis of drugs like ambroxol hydrochloride.
| Attribute | Details |
|---|---|
| Chemical Name | Trans-4-Aminocyclohexanol |
| Synonyms | trans-4-Amino-1-cyclohexanol; (trans)-4-Aminocyclohexan-1-ol; Trans-4-Aminocyclohexanol; trans-4-Aminocyclohexan-1-ol; Trans-p-Aminocyclohexanol; 4-Aminocyclohexanol, trans-; Anti-4-aminocyclohexanol |
| CAS Number | 27489-62-9 |
| Molecular Formula | C6H13NO |
| Molecular Weight | 115.17 g/mol |
| Appearance | White or pale yellow crystalline powder, which may darken upon exposure to light or prolonged storage |
| Melting Point | 108-113°C (may vary slightly depending on purity and crystallization conditions) |
| Boiling Point | 127°C at 14 mmHg (or 201.1±33.0°C at 760 mmHg) |
| Density | Approximately 0.9837 g/cm³ (or 1.0±0.1 g/cm³) |
| Solubility | Soluble in organic solvents such as chloroform; exhibits strong hygroscopicity |
| Chemical Properties | Trans-4-Aminocyclohexanol is a cyclic amino alcohol with an amino group and a hydroxyl group in a trans configuration on the cyclohexane ring. It is a stable compound under normal conditions and can participate in various organic reactions, such as condensation, acylation, and alkylation. |
| Applications | It serves as an important intermediate in the synthesis of drugs, such as Ambroxol hydrochloride. It can also react with various compounds to produce valuable derivatives. Additionally, it has potential applications in the fields of liquid crystals, epoxy resin curing agents, and chiral pesticides. |
| Safety Information | Handle with caution. Avoid contact with skin, eyes, and clothing. Wear appropriate protective clothing, gloves, and eye protection. Store in a cool, dry place away from incompatible materials and oxidizing agents. Follow local regulations for the safe handling and disposal of chemicals. |
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