TPCA-1
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms 5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide
Catalog ID92649
CAS NO.507475-17-4
Purity 98%
MDL NumberMFCD09037541
EINEC Molecular FormulaC12H10FN3O2S
Molecular Weight 279.29
Boiling point:442.576°C at 760 mmHg
| Category | Content |
|---|---|
| Name | TPCA-1 (TPCA1, IKK2 Inhibitor IV, GW683965) |
| Chemical Formula | C12H10FN3O2S |
| CAS Number | 507475-17-4 |
| Molecular Weight | 279.29 g/mol |
| Mechanism of Action | TPCA-1 is a potent and selective inhibitor of IKK-2 with an IC50 of 17.9 nM. It also inhibits STAT3 phosphorylation, DNA binding, and transactivation. |
| Target Pathways | – NF-κB signaling pathway<br>- JAK/STAT signaling pathway |
| Applications | – Research: Used to study inflammation, apoptosis, and cell signaling.<br>- Medicine: Investigated for potential use in treating diseases related to NF-κB and STAT3 signaling, such as cancer and inflammatory conditions. |
| Biological Activity | – Inhibits TNF-α, IL-6, and IL-8 production in LPS-stimulated human monocytes.<br>- Reduces collagen-induced arthritis severity in mice.<br>- Inhibits proliferation of cancer cells with constitutive STAT3 activation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year. |
| Solubility | H2O: Insoluble <br>Ethanol: 2.8 mg/mL (10 mM) <br>DMSO: 1 mg/mL, sonication recommended. |
| Safety | – Store in a dry place and protect from moisture.<br>- Handle with care to avoid inhalation or ingestion. |
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