Tosylmethyl isocyanide
Pharmaceutical Materials 2025-03-02
CAS Number: 36635-61-7.
Molecular Formula: C9H9NO2S.
Molecular Weight: 195.24 g/mol.
Appearance: Usually a pale yellow to white solid.
Usage: It is an important intermediate in organic synthesis, especially for the synthesis of heterocyclic compounds, ketones, and other diverse compounds.
| Attribute | Details |
|---|---|
| Chemical Name | Tosylmethyl isocyanide |
| Synonyms | TosMIC, 4-Toluenesulfonylmethyl isocyanide, (p-Tolylsulfonyl)methyl isocyanide |
| CAS Number | 36635-61-7 |
| Formula | C9H9NO2S |
| Molecular Weight | 195.24 g/mol |
| Structure | Heterocyclic compound with sulfonyl and isocyanide functionalities |
| Appearance | Colorless to pale yellow liquid or white solid (dependent on purity and storage conditions) |
| Properties | Moderately stable; Soluble in organic solvents; Insoluble in water; Moisture-sensitive |
| Melting Point | 109-115 °C (literature values may vary slightly) |
| Density | Approximately 1.2721 g/cm³ (estimated) |
| Refractive Index | 1.5270 (estimated) |
| Applications | Used as a synthetic reagent in organic chemistry; Specifically used in the preparation of biologically active heterocycles such as pyrroles and imidazoles; Acts as an isocyanide component in stereoselective Passerini reactions involving sugar-derived aldehydes |
| Safety Information | Hazardous; May cause irritation to eyes, skin, and respiratory tract; Handle in a well-ventilated area with appropriate personal protective equipment; Store under controlled conditions to prevent decomposition or leakage |
| Storage Conditions | Store in a cool, dry place away from heat, sparks, and incompatible materials; Keep container tightly sealed to prevent moisture ingress and loss of volatiles |
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