Tilorone 2HCl
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80020576
CAS NO.27591-69-1
Purity 95%
MDL NumberMFCD00134071
Colecular FormulaC25H34N2O3.2HCl
Molecular Weight483.4709
Melting point: 230~234°C”
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₂₅H₃₆Cl₂N₂O₃<br>- Molecular Weight: 483.47 g/mol |
| Physical Properties | – Appearance: Orange-yellow crystalline powder<br>- Melting Point: 230-233°C (lit.)<br>- Solubility: Slightly soluble in methanol |
| Mechanism of Action | – Induces interferon production, enhancing antiviral activity.<br>- Exhibits antitumor, anti-inflammatory, and neuroprotective effects.<br>- Affects mitochondrial membrane potential in isolated rat hepatocytes. |
| Applications | – Antiviral: Used to treat influenza, herpes, viral hepatitis, acute respiratory viral infections, and SARS.<br>- Antitumor: Used as an adjuvant in the treatment of malignant melanoma, gastric cancer, and secondary thrombocytopenia.<br>- Anti-inflammatory: Used for treating inflammatory conditions. |
| Pharmacokinetics | – Oral bioavailability with 52% human plasma protein binding.<br>- Mouse liver microsome half-life: 48 minutes.<br>- Effective doses in mice: 25-50 mg/kg (i.p.). |
| Safety Information | – Toxicity: LD₅₀ in mice and rats (oral): 959, 852 mg/kg; (i.p.): 145, 244 mg/kg.<br>- Storage: Sealed in a dry place at room temperature.<br>- Hazards: Harmful by inhalation, in contact with skin, and if swallowed. |
| Synonyms | – Tilorone dihydrochloride<br>- 2,7-Bis-9-fluorenone dihydrochloride<br>- Tilorone hydrochloride |
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