Active Pharmaceutical Ingredients

Molecular Formula: C46H83N2O17P

Molecular Weight: 967.128

CAS No.: 137330-13-3

It is a chemical semi-synthetic macrolide antibiotic, it is It is a new animal-specific drug with a broad antibacterial spectrum.

Description

It is an almost white or yellowish powder. It is mainly used to control bovine pneumonia and mastitis caused by sensitive bacteria, as well as mycoplasma disease in pigs and chickens.

Application

It is a chemical semi-synthetic macrolide antibiotic. It is a new animal-specific drug with a broad antibacterial spectrum. Tilmicosin phosphate has a strong inhibitory effect on Gram-negative and positive bacteria, mycoplasma and spirochetes.

In clinic, Tilmicosin phosphate is mainly used for respiratory diseases caused by Actinomyces pleuropneumoniae, Pasteurella hemolyticus, Pasteurella multocida, and livestock and poultry bodies.

Packing

25kg/drum or as customer’s requirements.

Storage

Store in airtight, tamper- proof container.

Minimum Order

One package

Tilmicosin Phosphate Introduction

Item	Details
Basic Information	Tilmicosin phosphate is a semi – synthetic macrolide antibiotic. Its chemical formula is C₄₄H₇₇NO₁₃·H₃PO₄. It appears as a white to off – white powder. It has good solubility in water, which is beneficial for formulating it into various pharmaceutical preparations for veterinary use, such as oral solutions, injectable solutions, and premixes. The phosphate salt form helps improve the solubility and stability of tilmicosin in aqueous environments.
Pharmacological Action	Tilmicosin phosphate acts by binding to the 50S subunit of the bacterial ribosome. This binding inhibits the elongation of the polypeptide chain during protein synthesis. Specifically, it interferes with the translocation process, preventing the movement of the ribosome along the messenger RNA. As a result, bacterial protein synthesis is disrupted, leading to the inhibition of bacterial growth. It has a relatively narrow – spectrum antibacterial activity, mainly targeting Gram – positive bacteria and some mycoplasmas. Against Gram – positive bacteria, it is highly effective against Streptococcus species, including Streptococcus suis, which is a common pathogen in pigs. It also shows significant activity against mycoplasmas, such as Mycoplasma hyopneumoniae in pigs and Mycoplasma gallisepticum in poultry.
Clinical Applications	1. Veterinary Medicine – Porcine Infections: – In pig farming, it is widely used to treat respiratory tract infections. For example, it can effectively treat porcine enzootic pneumonia caused by Mycoplasma hyopneumoniae. It can also be used to combat infections caused by Streptococcus suis, which can cause meningitis, arthritis, and respiratory problems in pigs. 2. Veterinary Medicine – Poultry Infections: – In poultry, it is used to treat respiratory infections caused by Mycoplasma gallisepticum. It helps in reducing the severity of respiratory symptoms such as coughing, sneezing, and nasal discharge in chickens and turkeys. 3. Feed Additive: – Tilmicosin phosphate can be used as a feed additive in livestock and poultry to prevent and control certain bacterial and mycoplasma infections. By including it in the feed, it can reach the target animals continuously and help maintain their health.
Adverse Reactions	1. Local Irritation: When administered by injection, tilmicosin phosphate can cause local irritation at the injection site. This may lead to swelling, pain, and tissue damage. In some cases, abscess formation may occur at the injection site. 2. Cardiotoxicity: In some animals, especially ruminants, tilmicosin phosphate can cause cardiotoxicity. It may lead to changes in heart rhythm and function, which can be life – threatening. The risk of cardiotoxicity is higher in cattle, and it is important to use the drug with caution in this species. 3. Gastrointestinal Effects: In animals, it can cause gastrointestinal upset, including diarrhea, vomiting, and loss of appetite. These symptoms are due to the drug’s effect on the normal gut flora and direct irritation of the gastrointestinal mucosa. 4. Allergic Reactions: Allergic reactions can occur in animals, ranging from mild rashes, itching, and hives to severe anaphylactic shock. Animals with a history of allergic reactions to macrolide antibiotics are at a higher risk.
Drug Interactions	1. With Other Macrolide Antibiotics: Concurrent use with other macrolide antibiotics may lead to overlapping effects and an increased risk of side effects, such as cardiotoxicity and gastrointestinal disturbances. 2. With Calcium – containing Compounds: Calcium – containing compounds, such as calcium – rich feeds or supplements, can chelate with tilmicosin, reducing its absorption. It is recommended to avoid administering tilmicosin phosphate with calcium – containing substances. 3. With Some Antacids: Antacids may also affect the absorption of tilmicosin phosphate by altering the pH of the gastrointestinal tract. It is advisable to separate the administration of tilmicosin phosphate and antacids by a certain time interval.
Special Population Considerations	1. Pregnant and Lactating Animals: The use of tilmicosin phosphate in pregnant and lactating animals should be carefully considered. Although the exact risk to the fetus or nursing offspring is not fully understood, the potential for adverse effects, such as cardiotoxicity and gastrointestinal problems, may pose a risk. In some cases, alternative antibiotics may be preferred. 2. Young and Elderly Animals: Young animals may be more sensitive to the adverse effects of tilmicosin phosphate due to their immature organ function. Elderly animals may also be at a higher risk, especially for cardiotoxicity and gastrointestinal effects, as their physiological function may be declining. 3. Ruminants: As mentioned, ruminants are particularly sensitive to the cardiotoxic effects of tilmicosin phosphate. Special care should be taken when using the drug in cattle, sheep, and goats. Dosage adjustments and close monitoring are necessary to avoid life – threatening cardiac problems.

 

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