Tilmicosin Phosphate CAS 137330-13-3
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Molecular Formula:C46H83N2O17P
Molecular Weight:967.128
CAS No.:137330-13-3
Description:This product is light yellow powder, soluble in water. And its effective component is tilmicosin, but it has good water solubility and is easy to be absorbed by the body. Therefore, it can be directly used for drinking water administration to poultry. At the same time, it has the advantages of fast oral absorption, strong tissue penetration, large distribution volume, higher drug concentration in alveolar tissue than in plasma, and thus quickly reaching the infected site
Application:It is mainly used to prevent and treat bovine pneumonia and mastitis caused by sensitive bacteria, as well as Mycoplasma disease in pigs and chickens.
Packing:25kg/drum or as customer’s requirements.
Storage:Store in airtight, tamper- proof container.
Tilmicosin Phosphate: A Veterinary Antibiotic
Tilmicosin Phosphate is a significant antibiotic in veterinary practice, widely used for treating and preventing specific infections in livestock and poultry.
1. General Information
| Aspect | Details |
| Classification | Macrolide antibiotic |
| Source | Semi – synthetic derivative of tylosin |
| Formulation | Available as powders, premixes for feed, and soluble powders for drinking water. Injectable formulations are also common. |
| Solubility | Soluble in water, which facilitates its administration via drinking water or in feed for animals. However, proper mixing is required to ensure uniform distribution. |
2. Mechanism of Action
| Action | Explanation |
| Inhibition of Protein Synthesis | Tilmicosin Phosphate binds to the 50S ribosomal subunit of bacteria. This binding interferes with the translocation process during protein synthesis. It prevents the ribosome from moving along the mRNA, thus halting the elongation of the polypeptide chain. As a result, bacterial protein synthesis is inhibited, leading to growth arrest and eventual cell death. |
| Selective Activity | It mainly targets Gram – positive bacteria, as well as mycoplasmas. The unique structure of the ribosomes in these organisms allows for specific binding of tilmicosin phosphate, enabling its antibacterial and antimycoplasmal effects. |
3. Clinical Applications and Considerations
| Category | Details |
| Applications | – Treating respiratory tract infections in cattle, sheep, and pigs. In cattle, it is effective against Mannheimia haemolytica, Pasteurella multocida, and Mycoplasma bovis, which are common causative agents of bovine respiratory disease. In pigs, it combats respiratory infections caused by Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae. – Used to control certain systemic infections in livestock. – Sometimes used as a growth promoter in livestock farming to improve feed conversion efficiency and enhance weight gain in some cases. |
| Considerations | – Overuse may lead to the development of antibiotic – resistant bacteria. So, following veterinary – recommended dosage and treatment duration is essential. – Injection – site reactions can occur in animals, such as swelling, pain, and local tissue damage. Proper injection techniques and site selection are crucial to minimize these side effects. – Caution is needed when using it in combination with other drugs, as there may be potential drug – drug interactions that could affect its efficacy or increase the risk of side effects. – It can be toxic to some species, like horses, and should not be used in them. |
Tilmicosin Phosphate plays a vital role in maintaining the health and productivity of livestock and poultry in veterinary medicine.
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