Tigecycline
Active Pharmaceutical Ingredients 2025-03-11
CAS NO.:220620-09-7
Molecular formula:C29H39N5O8
Molecular weight:585.65
Standard:enterprise standard
Content：≥99.0%
Packaging:1KG/TIN
Tigecycline: A Versatile Antibacterial Agent
Tigecycline is an important antibacterial agent that has found wide – spread use in the treatment of various infections.
1. General and Pharmacokinetic Information
| Aspect | Details |
| Chemical Class | Glycylcycline, a derivative of minocycline |
| Administration | Intravenous infusion |
| Distribution | Distributes widely in the body tissues, with high concentrations in many organs such as the lungs, kidneys, and liver. It can cross the blood – brain barrier to a certain extent. |
| Metabolism | Metabolized in the liver mainly by glucuronidation. |
| Elimination | Excreted in both feces and urine. The elimination half – life is approximately 27 – 42 hours. |
2. Mechanism of Action
| Action | Explanation |
| Inhibition of Protein Synthesis | Tigecycline binds to the 30S ribosomal subunit of bacteria. This binding blocks the entry of amino – acyl tRNA into the A – site of the ribosome, preventing the addition of new amino acids to the growing polypeptide chain. As a result, protein synthesis in bacteria is inhibited, leading to the arrest of bacterial growth and eventually cell death. |
3. Clinical Applications and Adverse Effects
| Category | Details |
| Clinical Applications | Used to treat a broad spectrum of infections, including those caused by Gram – positive bacteria (such as methicillin – resistant Staphylococcus aureus, MRSA), Gram – negative bacteria (like Escherichia coli, Klebsiella pneumoniae), and some anaerobes. It is effective in treating complicated skin and soft – tissue infections, complicated intra – abdominal infections, and community – acquired pneumonia. |
| Adverse Effects | Gastrointestinal side effects are common, including nausea, vomiting, and diarrhea. It may also cause hepatotoxicity, manifested as increased liver enzyme levels. In some cases, it can lead to prolongation of the QT interval, which may increase the risk of cardiac arrhythmias. |
Tigecycline offers a valuable option for treating difficult – to – treat bacterial infections, but its use requires careful monitoring due to potential side effects.
