Tideglusib
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID92648
CAS NO.865854-05-3
Purity 98%
MDL NumberMFCD18633296
Molecular FormulaC19H14N2O2S
Molecular Weight334.392
| Category | Content |
|---|---|
| Name | Tideglusib (NP-031112, NP-12) |
| Chemical Formula | C19H14N2O2S |
| CAS Number | 865854-05-3 |
| Molecular Weight | 334.39 g/mol |
| Mechanism of Action | Tideglusib is an irreversible, non-ATP competitive inhibitor of GSK-3β. It inhibits GSK-3β WT and GSK-3β C199A with IC50 values of 5 nM and 60 nM, respectively. |
| Target Pathways | – GSK-3β signaling pathway<br>- Wnt signaling pathway |
| Applications | – Research: Used to study neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease.<br>- Medicine: Investigated for potential treatment of neurodegenerative diseases, progressive supranuclear palsy (PSP), and myotonic dystrophy. |
| Biological Activity | – Reduces tau protein phosphorylation and amyloid plaque accumulation.<br>- Exhibits neuroprotective and anti-inflammatory effects in animal models. |
| Physical Properties | – Appearance: White to off-white crystalline solid.<br>- Solubility: Soluble in DMSO (≥50 mg/mL) .<br>- Stability: Stable at room temperature, hygroscopic. |
| Storage | Store at -25 to -15°C, protect from moisture and light. |
| Safety | – Handle with care to avoid contact with skin and eyes.<br>- Ensure proper ventilation during handling.<br>- For research use only. |
| Synonyms | 4-Benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione, NP-031112, NP-12. |
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