Ticagrelor CAS No.: 274693-27-5
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Category：Pharmaceutical Materials Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Ticagrelor, marketed under brand names such as Brilinta® and Brilique®, is an oral, reversible P2Y12 adenosine diphosphate (ADP) receptor antagonist used to reduce thrombotic cardiovascular events in patients with acute coronary syndrome (ACS) or those undergoing percutaneous coronary intervention (PCI). Its CAS number is 274693-27-5, with a molecular formula of C₂₃H₂₈F₂N₆O₄S and a molecular weight of 522.57 g/mol. Ticagrelor inhibits platelet aggregation by blocking the P2Y12 receptor, offering a faster onset of action compared to clopidogrel. Approved by the FDA in 2011, it has demonstrated superiority in reducing cardiovascular mortality and stent thrombosis in clinical trials like PLATO. Safety considerations include a risk of bleeding, dyspnea, and potential interactions with CYP3A4 inhibitors or inducers.
Usage： Used as an anticoagulant to reduce cardiovascular death and heart attacks in patients with acute coronary syndrome (ACS).
Packaging and Shipping： 25KG/drum or as per buyer requirement.
Storage: Stored in a cool, ventilated warehouse, should be separated from oxidizer, edible chemicals, do not mix storage. Keep container closed and away from fire and heat.
| Name | Ticagrelor (Brilinta/Brilique) |
| CAS No. | 274693-27-5 |
| Molecular Formula | C₂₃H₂₈F₂N₆O₄S |
| Molecular Weight | 522.57 g/mol |
| Appearance | White solid |
| Indications | Acute coronary syndrome (ACS), unstable angina, myocardial infarction (MI) |
| Mechanism | Reversible P2Y12 receptor antagonist; inhibits platelet aggregation |
| Pharmacokinetics | Rapid absorption (Tmax=2-3h), high plasma protein binding (>99.8%), metabolized via CYP3A4/3A5, half-life=6.7-9.1h |
| Adverse Effects | Dyspnea, bleeding (nose/subcutaneous), rare allergic reactions, hepatotoxicity |
| Storage | Sealed, cool (room temperature), dry conditions |
| Packaging | 10mg, 25mg, 50mg (customizable) |
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