TIC-10
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID92643
CAS NO.41276-02-2
Purity 98%
MDL Number Molecular Formula C24H26N4O
Molecular Weight 386.489
Boiling point: 559.7°C at 760mmHg
| Category | Content |
|---|---|
| Name | TIC-10 (ONC-201) |
| Chemical Formula | C24H26N4O |
| CAS Number | 41276-02-2 |
| Molecular Weight | 386.49 g/mol |
| Mechanism of Action | TIC-10 is a dual inhibitor of Akt and ERK, leading to the upregulation of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through Foxo3a. It induces TRAIL-mediated apoptosis in cancer cells. |
| Biological Activity | – In Vitro: Causes a dose-dependent increase in TRAIL mRNA and protein localization on the cell surface of cancer cell lines. It induces cell death in TRAIL-sensitive cancer cells but spares normal fibroblasts.<br>- In Vivo: Induces tumor regression in various cancer xenograft models, including colon cancer and triple-negative breast cancer. |
| Applications | – Research: Studied for its effects on cancer cell apoptosis and tumor regression.<br>- Medicine: Investigated as a potential antitumor therapeutic agent for various cancers, including glioblastoma multiforme. |
| Physical Properties | – Appearance: White to beige solid.<br>- Solubility: Soluble in DMSO (2 mg/mL, clear upon heating).<br>- Storage: 2-8°C. |
| Safety | – Handle with care to avoid contact with skin and eyes.<br>- Store in a cool, dry place. |
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