Active Pharmaceutical Ingredients

Catalog ID92643

CAS NO.41276-02-2

Purity 98%

MDL Number Molecular Formula C24H26N4O

Molecular Weight 386.489

Boiling point: 559.7°C at 760mmHg

Category	Content
Name	TIC-10 (ONC-201)
Chemical Formula	C24H26N4O
CAS Number	41276-02-2
Molecular Weight	386.49 g/mol
Mechanism of Action	TIC-10 is a dual inhibitor of Akt and ERK, leading to the upregulation of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through Foxo3a. It induces TRAIL-mediated apoptosis in cancer cells.
Biological Activity	– In Vitro: Causes a dose-dependent increase in TRAIL mRNA and protein localization on the cell surface of cancer cell lines. It induces cell death in TRAIL-sensitive cancer cells but spares normal fibroblasts.<br>- In Vivo: Induces tumor regression in various cancer xenograft models, including colon cancer and triple-negative breast cancer.
Applications	– Research: Studied for its effects on cancer cell apoptosis and tumor regression.<br>- Medicine: Investigated as a potential antitumor therapeutic agent for various cancers, including glioblastoma multiforme.
Physical Properties	– Appearance: White to beige solid.<br>- Solubility: Soluble in DMSO (2 mg/mL, clear upon heating).<br>- Storage: 2-8°C.
Safety	– Handle with care to avoid contact with skin and eyes.<br>- Store in a cool, dry place.

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