Active Pharmaceutical Ingredients

Molecular Formula: C32H51NO8S

Molecular Weight : 609.814

CAS No.: 55297-96-6

Description：It is white or off white crystalline powder, odorless and tasteless. Soluble in methanol or ethanol, soluble in water, slightly soluble in acetone, almost insoluble in hexane.

Application:It can be used for chronic respiratory diseases in chickens, Mycoplasma hyopneumoniae pneumonia and Hemophilus pleuropneumonia. It can also be used for diarrhea caused by Treponema hyopneumoniae.

Packing:25kg/drum or as customer’s requirements.

Storage:Preserve in tight, light-resistant containers, and store at room temperature.

Tiamulin Hydrogen Fumarate: A Veterinary Antibiotic

Tiamulin Hydrogen Fumarate is an important antibiotic in the realm of veterinary medicine, widely utilized for treating and preventing specific infections in livestock and poultry.

1. General Information

Aspect	Details
Classification	Pleuromutilin antibiotic
Source	Semi – synthetic derivative of pleuromutilin, which is naturally produced by the basidiomycete Pleurotus mutilus
Formulation	Available in various forms such as powders, premixes for feed, and soluble powders for drinking water. There are also injectable formulations for certain applications.
Solubility	Soluble in water to some extent, allowing for easy administration through drinking water systems in animals. However, its solubility characteristics may require careful handling to ensure uniform distribution.

2. Mechanism of Action

Action	Explanation
Inhibition of Protein Synthesis	Tiamulin Hydrogen Fumarate binds to the 50S ribosomal subunit of bacteria. This binding disrupts the peptidyl transferase activity, which is essential for the formation of peptide bonds during protein synthesis. As a result, the elongation of the polypeptide chain is blocked, and bacterial protein synthesis is inhibited.
Selective Activity	It primarily targets Gram – positive bacteria, as well as mycoplasmas. The unique architecture of the ribosomes in these organisms enables the specific binding of tiamulin hydrogen fumarate, leading to its antibacterial and antimycoplasmal effects.

3. Clinical Applications and Considerations

Category	Details
Applications	– Treating respiratory tract infections in pigs, poultry, and cattle. In pigs, it is effective against Mycoplasma hyopneumoniae, which causes enzootic pneumonia. In poultry, it helps combat respiratory mycoplasmosis. – Controlling enteric infections, especially swine dysentery caused by Brachyspira hyodysenteriae. It can also be used to manage other intestinal infections in livestock. – Sometimes used as a growth promoter in livestock farming, as it can improve feed conversion efficiency and enhance weight gain in certain cases.
Considerations	– Prolonged or improper use can lead to the emergence of antibiotic – resistant bacteria. Thus, strict adherence to veterinary – recommended dosage and treatment duration is crucial. – May cause mild side effects in some animals, such as gastrointestinal disturbances like diarrhea or reduced appetite. Monitoring animals during treatment is necessary to detect and manage these potential adverse reactions. – Caution should be exercised when using it in combination with other drugs, as there may be potential drug – drug interactions that could affect its efficacy or increase the risk of side effects.

Tiamulin Hydrogen Fumarate serves as a valuable tool in veterinary medicine for maintaining the health and productivity of livestock and poultry.

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