Thymoquinon
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80071767
CAS NO.490-91-5
Purity 98%
MDL NumberMFCD00001602
EINEC207-721-1
Molecular formula C10H12O2
Molecular weight 164.2011
Melting point: 44~46°C
Boiling point: 230~232°C
| Item | Information |
|---|---|
| Compound Name | Thymoquinone (2-Isopropyl-5-methylbenzo-1,4-quinone) |
| Source | Thymoquinone is a bioactive compound derived from the seeds of Nigella sativa, commonly known as black cumin. |
| Mechanism of Action | Thymoquinone exhibits antioxidant, anti-inflammatory, and anticancer properties. It modulates various molecular and signaling pathways involved in inflammation, oxidative stress, and cancer. |
| Pharmacological Properties | – Antioxidant: Scavenges free radicals and upregulates natural antioxidants like superoxide dismutase (SOD) and catalase.<br>- Anti-inflammatory: Inhibits pro-inflammatory cytokines and enzymes.<br>- Anticancer: Induces apoptosis and inhibits tumor growth in various cancer cell lines.<br>- Neuroprotective: Reduces seizure activity and protects against neurodegenerative diseases. |
| Applications | – Traditional use in treating asthma, hypertension, diabetes, and inflammation.<br>- Investigated for potential use in cancer treatment, neurodegenerative diseases, and other inflammatory conditions. |
| Bioavailability and Formulation Challenges | Thymoquinone has high lipophilicity and limited bioavailability. It is also sensitive to light and heat, which can hinder its formulation into conventional dosage forms. |
| Side Effects | Common side effects include gastrointestinal discomfort, nausea, and rash. |
| Future Directions | Further clinical trials are needed to translate the experimental findings into human applications. |
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