Thiamphenicol CAS 15318-45-3
Category：Active Pharmaceutical Ingredients
Introduction
Thiamphenicol is a broad-spectrum antibiotic of chloramphenicol, which has stronger effect on Gram-negative bacteria than positive bacteria. Its chemical structure is similar to that of chloramphenicol. Its methylsulfone group replaces the nitro group of chloramphenicol, so its toxicity is reduced, and its antibacterial effect in the body is 2.5-5 times stronger than that of chloramphenicol.
Molecular Formula：C12H15Cl2NO5S
Molecular Weight：356.2
CAS No.: 15318-45-3
Description
Thiamphenicol is a fine, white or yellowish-white, crystalline powder or crystals. It is slightly soluble in water, very soluble in dimethylacetamide, freely soluble in acetonitrile and in dimethylformamide, soluble in methanol, sparingly soluble in acetone and in anhydrous ethanol, slightly soluble in ethyl acetate.
Application
Thiamphenicol is a broad-spectrum antibiotic of chloramphenicol, which has stronger effect on Gram-negative bacteria than positive bacteria. Its chemical structure is similar to that of chloramphenicol. Its methylsulfone group replaces the nitro group of chloramphenicol, so its toxicity is reduced, and its antibacterial effect in the body is 2.5-5 times stronger than that of chloramphenicol.
In clinic, thiamphenicol is mainly used in the treatment of respiratory, urinary, hepatobiliary, typhoid and other intestinal surgery, obstetrics and Gynecology and ENT infection, especially for mild infection. Thiamphenicol has strong antibacterial activity against Gram-positive bacteria such as pneumococci and hemolytic streptococcus, and it has strong antibacterial activity against Gram-positive bacteria such as Neisseria gonorrhoeae, diplococcus meningitidis, pulmonary Bacteroides, Escherichia coli, Vibrio cholerae, dysentery and influenza, it also has certain antibacterial activity against anaerobic bacilli, Rickettsia and amoeba, the mechanism of action is the same as that of chloramphenicol.
Thiamphenicol also has a strong immunosuppressive effect and is an excellent immunosuppressant. Its mechanism of action is significantly different from other immunosuppressive agents, and its immunosuppressive effect is several times higher than that of chloramphenicol.
Packing and Storage
Preserve in an airtight container, protected from light.
Minimum Order
One package
