Thalidomide-O-PEG5-Tosyl
Biomedicine 2025-03-04
CAS NO.: 2414905-34-1
Product purity: ≥95%
Molecular formula: C30H36N2O12S
Molecular weight: 648.68
Product Usage: Used in medical research, drug release, nanotechnology and new material research, cell culture. As well as in ligand research, peptide synthesis support, grafted polymer compounds, new materials and polyethylene glycol modified functional coatings and other active compounds.
Basic Information
| Item | Description |
|---|---|
| Full Name | Thalidomide-O-PEG5-Tosyl |
| CAS Number | 2414905-34-1 |
| Molecular Formula | C30H36N2O12S |
| Molecular Weight | 668.67 |
| Purity | ≥98% |
| Appearance | White to off-white solid or powder |
| Solubility | Soluble in DMSO, DMF, DCM, and water |
| Storage Conditions | -20°C, dry, protected from light |
Detailed Information
| Item | Description |
|---|---|
| Structure | Consists of a Thalidomide core, a PEG chain with five ethylene oxide units, and a tosylate (p-toluenesulfonate) group |
| Reactivity | The tosylate group is a good leaving group, making it reactive with nucleophiles such as amines and thiols |
| Applications | – PROTAC Technology: Used as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.<br>- Medical Research: Applied in drug release, nanotechnology, and cell culture.<br>- Material Science: Used in the synthesis of functional coatings and polymers. |
| Advantages | – Combines the properties of Thalidomide, PEG, and a reactive tosylate group.<br>- High biocompatibility and versatility in bioconjugation. |
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