Thalidomide-O-PEG4-N3
Biomedicine 2025-03-04
CAS NO.: 2380318-57-8
Product purity: ≥ 95%
Molecular formula: C23H29N5O9
Molecular weight: five hundred and nineteen point five one
Product application: Used in medical research, drug release, nanotechnology and new material research, cell culture. As well as ligand research, peptide synthesis support, grafting of polymer compounds, new materials, and polyethylene glycol modified functional coatings and other active compounds.
Basic Information
| Item | Description |
|---|---|
| Full Name | Thalidomide-O-PEG4-Azide |
| CAS Number | 2380318-57-8 |
| Molecular Formula | C23H29N5O9 |
| Molecular Weight | 519.5 g/mol |
| Purity | ≥95% |
| Appearance | White to off-white solid or powder |
| Solubility | Soluble in DMSO, DMF, DCM, and water |
| Storage Conditions | -20°C, dry, protected from light |
Detailed Information
| Item | Description |
|---|---|
| Structure | Consists of a Thalidomide core, a PEG chain with four ethylene oxide units, and an azide (N3) group |
| Reactivity | The azide group can undergo click chemistry reactions with alkynes to form stable triazole linkages |
| Applications | – PROTAC Technology: Used as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.<br>- Medical Research: Applied in drug release, nanotechnology, and cell culture.<br>- Material Science: Used in the synthesis of functional coatings and polymers. |
| Advantages | – Combines the properties of Thalidomide, PEG, and a reactive azide group.<br>- High biocompatibility and versatility in bioconjugation. |
