Thalidomide-O-amido-PEG2-NH2.TFA
Biomedicine 2025-03-04
CAS NO.: 1957235-75-4
Product purity: ≥95%
Molecular formula: c23h27f3n4o10
Molecular weight: 576.48
Product Usage: Used in medical research, drug release, nanotechnology and new material research, cell culture. As well as in ligand research, peptide synthesis support, grafted polymer compounds, new materials and polyethylene glycol modified functional coatings and other active compounds.
Basic Information
| Item | Description |
|---|---|
| Full Name | Thalidomide-O-amido-PEG2-NH2.TFA |
| CAS Number | 1957235-75-4 |
| Molecular Formula | C23H27F3N4O10 |
| Molecular Weight | 576.48 |
| Purity | ≥95% |
| Appearance | White to off-white solid or powder |
| Solubility | Soluble in water, DMSO, DMF, DCM |
| Storage Conditions | -20°C for powder, -80°C for solutions |
Detailed Information
| Item | Description |
|---|---|
| Structure | Contains a Thalidomide core linked to a PEG chain with two ethylene oxide units, terminated with an amide group and an amino group in the form of trifluoroacetate (TFA) salt |
| Reactivity | The amino group can react with carboxyl groups to form amide bonds or with aldehydes to form Schiff bases |
| Applications | – PROTAC Technology: Used as a linker in the synthesis of Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.<br>- Medical Research: Applied in drug release, nanotechnology, and cell culture.<br>- Material Science: Used in the synthesis of functional coatings and polymers. |
| Advantages | – Combines the properties of Thalidomide, PEG, and a reactive amino group.<br>- High biocompatibility and versatility in bioconjugation. |
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