Tetracycline hydrochloride CAS NO：64-75-5
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS NO：64-75-5
64-75-5 – Names and Identifiers
| Name | Tetracycline Hydrochloride |
| Synonyms | alatet cyclopar artomycin cancycline-250 Tetracycline hcl cefracyclinetablets amycin,hydrochloride chlorowodorkutetracykliny Tetracycline Hydrochloride chlorhydratedetetracycline (2E,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride (2Z,4S,4aS,5aS,6S,12aS)-2-[amino(hydroxy)methylidene]-4-(dimethylamino)-6,10,11,12a-tetrahydroxy-6-methyl-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione hydrochloride [4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha)]-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide hydrochloride |
| CAS | 64-75-5 1170-81-6 |
| EINECS | 200-593-8 |
| InChI | InChI=1/C22H24N2O8.ClH/c1-21(31)8-5-4-6-11(25)12(8)16(26)13-9(21)7-10-15(24(2)3)17(27)14(20(23)30)19(29)22(10,32)18(13)28;/h4-6,9-10,15,25,27-28,31-32H,7H2,1-3H3,(H2,23,30);1H |
| InChIKey | XMEVHPAGJVLHIG-FMZCEJRJSA-N |
64-75-5 – Physico-chemical Properties
| Molecular Formula | C22H25ClN2O8 |
| Molar Mass | 480.9 |
| Melting Point | 220-223°C(lit.) |
| Boling Point | 799.4°C at 760 mmHg |
| Specific Rotation(α) | -252 º (c=0.5, H2O) |
| Flash Point | 437.3°C |
| Water Solubility | 50 g/L |
| Solubility | 20g/L water, 5g/L ethanol, insoluble in ether, hydrocarbon and acetone. |
| Vapor Presure | 5.82E-27mmHg at 25°C |
| Appearance | Yellow crystal |
| Color | faint yellow to yellow |
| Merck | 14,9196 |
| BRN | 3844873 |
| PH | pH(10g/l, 25℃) : 1.8～3.0 |
| Storage Condition | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| Sensitive | Air & Light Sensitive |
| Refractive Index | -253 ° (C=0.5, 0.1mo |
| MDL | MFCD00078142 |
| Use | Broad-spectrum antibiotics |
64-75-5 – Risk and Safety
| Risk Codes | R36/37/38 – Irritating to eyes, respiratory system and skin. R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed. |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing. |
| UN IDs | UN 3077 9 / PGIII |
| WGK Germany | 2 |
| RTECS | QI9100000 |
| FLUKA BRAND F CODES | 8-10-23 |
| TSCA | Yes |
| HS Code | 29413000 |
| Hazard Class | 3 |
| Toxicity | LD50 orally in rats: 6443 mg/kg (Goldenthal) |
64-75-5 – Reference
| Reference | 1. Wang Yu, Xu Jia, heading for Su Yu, Zhao Ge, Jiang Jingyan. Effects of three kinds of antimicrobial agents commonly used in veterinary clinic on urease and its mechanism of action by spectroscopic and molecular docking [J]. Journal of Nanjing Agricultural University, 2020,43(04):690-697. 2. Zhou Rui, Gui Rongjie, Zhang Jin, etc. Screening of cadmium and tetracycline contaminated soil tolerant strains and their ability to promote rhizosphere growth. 3. Xue Xiaoxu, Chen Changze, Gu Guowei. Adsorption of drug active compounds on magnetic chitosan composite microspheres modified by polyacrylic acid [J]. Yunnan chemical industry, 2020,47(08):48-51. 4. Wang Shihao, Shi Minghao, Liu Su. Combined toxic effects of tetracycline and arsenic on zebrafish in sequential exposure scenarios [J]. Journal of Environmental Science, 2020,40(12):4590-4597. 5. He Qian, Wang Loli, Yi Chuan, Wu Guiping. Preparation of MoS_2 @ MIL-53(Fe) and its photocatalytic degradation of antibiotics under visible light [J]. Environmental Science & Technology, 2020,43(08):13-19. 6. Xue Xiaoxu, Chen Changze, Gu Guowei. Adsorption of drug active compounds on magnetic chitosan composite microspheres modified by polyacrylic acid [J]. Yunnan chemical industry, 2020,47(08):48-51. 7. [IF = 7.658] Hong Zhang et al.”Uncariitannin, a polyphonic polymer from Uncaria gambier, attenuates New York USA through an MgrA-mediated review of alpha-hemolysin.” Pharmacol Res. 2019 Sep;147:104328 8. [IF = 7.514] Baoshan He et al.”Aptamer-based thin film gold electrode modified with gold nanoparticles and carboxylated multi-walled carbon nanotubes for detecting oxytetracycline in chicken samples.”Food Chem. 2019 Dec;300:125179 9. [IF=7.514] Yanan Cao et al.”Rapid and selective extraction of norfloxacin from milk using magnetic molecular imprinting polymers nanoparticles.”Food Chem. 2021 Aug;353:129464 10. [IF=7.086] Zhifen Chen et al.”In-situ synthesis of biochar modified PbMoO4: An efficient visible light-driven photocatalyst for tetracycline removal.”Chemosphere. 2021 Dec;284:131260 11. [IF=6.291] Yilin Liu et al.”Responses of Hydrocharis dubia (Bl.) Backer and Trapa bispinosa roxb. to tetracycline exposure.”Ecotox Environ Safe. 2020 Oct;202:110890 12. [IF=3.209] Liuliu Jiang et al.”In vitro and in vivo evaluation of the antifungal activity of fluoxetine combined with antifungals against Candida albicans biofilms and oral candidiasis.”Biofouling. 2020;36(5):537-548 13. [IF=2.478] Wang Lina et al.”Palygorskite/g-C3N4 conjunction for visible-light-driven degradation of tetracycline hydrochloride.”J Mater Sci-Mater El. 2019 Oct;30(19):18159-18167 14. [IF=5.316] Peiyu Cao et al.”Constructing nano-heterojunction of MOFs with crystal regrowth for efficient degradation of tetracycline under visible light.”J Alloy Compd. 2022 May;904:164061 15. [IF=8.067] Yuanting Xu et al.”“1 1>2”: Highly efficient removal of organic pollutants by composite nanofibrous membrane based on the synergistic effect of adsorption and photocatalysis.”J Mater Sci Technol. 2022 Oct;124:76 |
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