Tetrabutylphosphonium bromide
Pharmaceutical Materials 2025-03-02
CAS Number: 3115-68-2
Molecular Formula: C16H36BrP
Molecular Weight: 339.34 g/mol
Appearance: White solid or liquid
Usage: Widely used in organic synthesis as a phase-transfer catalyst.
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| Category | Details |
|---|---|
| Chemical Name | Tetrabutylphosphonium bromide |
| CAS Number | 3115-68-2 |
| Molecular Formula | C16H36BrP |
| Molecular Weight | 339.34 g/mol |
| Synonyms | Tetra-n-butylphosphonium bromide; Tetranbutylphosphonium bromide; Bromo(tetrabutyl)phosphorane; Phosphonium, tetrabutyl-, bromide; Tetrabutylphosphonium bromide white xtl; px4b; Tertabutylphosphoriun bromide; tetrabutyl-phosphoniubromide |
| Appearance | White to off-white crystalline powder or transparent to pale yellow liquid |
| Melting Point | 100-103°C (lit.) |
| Flash Point | 290°C |
| Solubility | Soluble in methanol, acetone, and toluene; water solubility is approximately 70 g/100 mL |
| Density | N/A |
| Boiling Point | N/A (decomposes before boiling) |
| Uses | Acts as a phase transfer catalyst and a pharmaceutical intermediate. Used as an ion-pair reagent in the synthesis of amoxicillin, sultamicillin, and other compounds. |
| Stability | Generally stable; hygroscopic, so should be stored in a sealed container in a cool, dry place. |
| Safety Information | May be harmful by inhalation, in contact with skin, and if swallowed. Irritating to eyes, respiratory system, and skin. Handle with care and wear appropriate personal protective equipment. Avoid ingestion and contact with mucous membranes. |
