tert-Butyl ((s)-4-methyl-1-((r)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate
Pharmaceutical Materials 2025-03-02
Catalog ID:92162
CAS NO.:247068-82-2
Purity:97%
MDL Number:MFCD22573306
Molecular Weight:271.353
| Chemical Name | tert-Butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate |
| CAS No. | 247068-82-2 |
| Molecular Formula | C₁₄H₂₅NO₄ |
| Molecular Weight | 271.35 g/mol |
| Chirality | Two stereocenters (S- and R-configurations) |
| Appearance | White to off-white solid or powder |
| Solubility | Soluble in polar solvents (e.g., DMSO, methanol); limited solubility in water |
| Key Functional Groups | Tert-butoxycarbonyl (Boc) protecting group, epoxy ketone, methylvaline residue |
| Synthesis | Multistep peptide coupling involving Boc-protected amino acids and epoxidation |
| Applications | Pharmaceutical intermediate for proteasome inhibitors (e.g., carfilzomib), drug discovery, and biochemical research. |
| Safety Information | GHS Hazard Statements: H315 (skin irritant), H319 (serious eye irritant), H335 (may cause respiratory irritation). Precautions: Avoid inhalation (P261), wear gloves/goggles (P280), and store in a sealed container at 2-8°C. |
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