tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
Category：Other Pharmaceutical
Introduction
4- [4- (4,4,5,5-tetramethyl-1,3,2-dioxacycloboran-2-yl) -1H-pyrazol-1-yl] piperidine-1-carboxylic acid tert butyl ester is an organic compound commonly referred to as TBDPS. The following is an introduction to the properties, uses, preparation methods, and safety information of the compound:
nature:
-Appearance: White solid
-Thermal stability: Stable
Purpose:
-TBDPS is a commonly used protective group that can be used to protect functional groups such as alcohols, phenols, and amines from accidental reactions or damage during chemical reactions.
Manufacturing method:
The synthesis of TBDPS is mainly carried out through the following steps:
-Reacting pyridine with 1H-pyrazole-1-carboxylic acid to generate 1-piperidine-1H-pyrazole-1-carboxylic acid ester.
-Then, the ester group was cleaved using sodium hydroxide induced by boric acid to obtain the target product TBDPS.
Security information:
TBDPS is relatively safe under normal conditions, but it still needs to be used and stored with caution, taking note of the following:
-TBDPS may be irritating to the eyes and skin, and should be immediately rinsed with water upon contact.
-When operating TBDPS, appropriate personal protective equipment such as gloves, goggles, etc. should be worn.
-TBDPS should be stored in a dry, cool place, away from sources of fire and flammable materials.
| Name | tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate |
| Synonyms | Crizotinib intermediates 2 Borate fragment of crizotinib 1-Piperidinecarboxylic acid, 4 1-(4-N-Boc-piperidine)pyrazole-4-boronic acid pinacol ester tert-Butyl 4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)piperidine-1-car tert-Butyl 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-yl]piperidine-1-carboxylate tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate 4-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-1-piperidinecarboxylic acid 1,1-dimethylethyl ester |
| CAS | 877399-74-1 |
| EINECS | 800-459-4 |
| InChI | InChI=1/C19H32BN3O4/c1-17(2,3)25-16(24)22-10-8-15(9-11-22)23-13-14(12-21-23)20-26-18(4,5)19(6,7)27-20/h12-13,15H,8-11H2,1-7H3 |
| Molecular Formula | C19H32BN3O4 |
| Molar Mass | 377.29 |
| Density | 1.14±0.1 g/cm3(Predicted) |
| Melting Point | 114.0 to 118.0 °C |
| Boling Point | 492.8±35.0 °C(Predicted) |
| pKa | 2.89±0.19(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| Refractive Index | 1.539 |
| Use | This product is for scientific research only and shall not be used for other purposes. |
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