Terdizolamide phosphate CAS NO.856867-55-5
Active Pharmaceutical Ingredients 2025-03-03
CAS NO.856867-55-5
| Name | Tedizolid phosphate |
| Synonyms | Tedizolid phosphate Tedizolid Phosphate Tedizolid phosphate impurity A -3-(4-(2-(2-Methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxyMethyl oxazolidin-2-one phosphate (R) -3-(4-(2-(2-Methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxyMethyl oxazolidin-2-one phosphate (5R)-3-[3-Fluoro-4-[6-(2-methyl-2H-tetrazol-5-yl)-3-pyridinyl]phenyl]-5-[(phosphonooxy)methyl]-2-oxazolidinone (R) -3- (4- (2- (2- methyl-tetrazol-5-yl) pyridin-5-yl) -3-fluorophenyl) -5-hydroxymethyl-oxazolidin-2-one phosphate (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridin-5-yl)-3-fluorophenyl)-5-hydroxymethyloxazolidin-2-one dihydrogenphosphate (R)-(3-(3-fluoro-4-(6-(2-methyl-2H-tetrazol-5-yl)pyridin-3-yl)phenyl)-2-oxooxazolidin-5-yl)methyl dihydrogen phosphate [(5R)-3-[3-fluoro-4-[6-(2-methyltetrazol-5-yl)pyridin-3-yl]phenyl]-2-oxo-1,3-oxazolidin-5-yl]methyl dihydrogen phosphate |
| CAS | 856867-55-5 |
| EINECS | 1592732-453-0 |
| Molecular Formula | C17H16FN6O6P |
| Molar Mass | 450.32 |
| Density | 1.75±0.1 g/cm3(Predicted) |
| Melting Point | >235°C (dec.) |
| Boling Point | 725.6±70.0 °C(Predicted) |
| Solubility | DMSO: ≥ 36 mg/mL |
| Appearance | Solid |
| Color | White to Off-White |
| pKa | 1.81±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Stability | Hygroscopic |
| Use | This product is for scientific research only and shall not be used for other purposes. |
| In vitro study | Tedizolid (TR-700) is the active part of the prodrug tedizolid phosphate (TR-701) and has activity against Gram-positive bacteria, including methicillin-resistant S. Aureus. Tedizolid is more than 4 times more potent in vitro to antagonize PRSP than linezolid. |
| In vivo study | Tedizolid has good permeability of lung epithelial mucus layer. Tedizolid phosphate is effective in antagonizing systemic infections in vivo by oral route or intravenous administration. Oral Tedizolid phosphate also effectively antagonized Pneumonia of the induction by the PSSP strain. |
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