Active Pharmaceutical Ingredients

Terbinafine hydrochloride is an acrylamine drug with broad-spectrum antifungal activity. This product can specifically interfere with the early biosynthesis of ergosterol in fungi, highly selectively inhibit the squalene cyclooxygenase of fungi, and block the squalene epoxidation reaction in the formation of fungal cell membrane, so as to kill or inhibit fungi.

Molecular Formula:C6H8N2O2S

Molecular Weight:327.9

CAS No.: 78628-80-5

Description

Terbinafine hydrochloride is a white or almost white powder. It is very slightly or slightly soluble in water, freely soluble in anhydrous ethanol and in methanol, slightly soluble in acetone.

Application

Skin, hair and nail infections caused by Trichophyton (Trichophyton albicans, Trichophyton mentagrophytes, Trichophyton verruciformis, Trichophyton broken and Trichophyton purple), Microsporum canis and Trichophyton flocculus. Chemicalbook2. Various ringworm diseases (tinea corporis, tinea cruris, tinea manus and pedis, tinea capitis, etc.) and skin yeast infection caused by Candida (Candida albicans, etc.). 3. Onychomycosis caused by Trichoderma (onychomycosis infection).

Packing and Storage

Preserve in well-closed containers, protected from light. Store at room temperature

Minimum Order

One package

Title	Content
Introduction	Terbinafine Hydrochloride is an antifungal medication used to treat a variety of fungal infections, including nail infections, ringworm, athlete’s foot, and jock itch. It works by inhibiting fungal cell membrane synthesis, effectively killing the fungus.
Mechanism of Action	Terbinafine inhibits the enzyme squalene epoxidase, which is essential for fungal cell membrane synthesis. This disruption prevents fungal growth and kills the fungus.
Medical Uses	– Nail Infections: Used to treat onychomycosis (fungal nail infections) with a typical oral dosage of 250 mg daily for 6 weeks (fingernails) or 12 weeks (toenails).<br>- Skin Infections: Effective for ringworm, athlete’s foot, and jock itch. Topical formulations are applied directly to the affected skin.<br>- Tinea Capitis: Oral terbinafine is used for scalp ringworm, with a typical course of 6 weeks.
Dosage Forms	Available as oral tablets (250 mg), topical creams, gels, sprays, and oral granules.
Common Side Effects	– Digestive Issues: Nausea, diarrhea, abdominal pain, and gas.<br>- Skin Reactions: Rash, itching, and skin peeling.<br>- Other: Headache, taste changes, and increased sensitivity to sunlight.
Serious Side Effects	– Liver Problems: Jaundice, dark urine, abdominal pain.<br>- Allergic Reactions: Anaphylaxis, severe skin reactions (e.g., blistering, peeling skin).<br>- Mood Changes: Depression, irritability.
Precautions	– Regular liver function tests are recommended, especially for long-term use.<br>- Avoid alcohol and direct sunlight.<br>- Inform your doctor about other medications you are taking to avoid interactions.
Storage Conditions	Store at room temperature (20°C to 25°C), protect from moisture and light.

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