Tenofovir alafenamide
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID92619 CAS NO.379270-37-8 Purity 98% MDL NumberMFCD23843796 Molecular Formula C21H29N6O5P Molecular Weight 476.466
Introduction to Tenofovir
| Attribute | Details |
|---|---|
| Definition | Tenofovir is a nucleotide analog reverse transcriptase inhibitor (NtRTI) used primarily for the treatment of HIV-1 infection and chronic hepatitis B (HBV) infection. |
| Mechanism of Action | Tenofovir inhibits viral replication by competing with the natural substrate deoxyadenosine 5′-triphosphate (dATP) for incorporation into viral DNA, leading to chain termination and inhibition of viral DNA synthesis. |
| Clinical Uses | – HIV-1 Infection: Used as part of combination antiretroviral therapy (ART) to suppress viral load and boost CD4+ cell counts.<br>- Chronic Hepatitis B: Effective in reducing HBV DNA levels to undetectable levels after prolonged treatment. |
| Pharmacokinetics | – Bioavailability: Low oral bioavailability in its parent form; administered as prodrugs (e.g., tenofovir disoproxil fumarate [TDF] or tenofovir alafenamide [TAF]) to enhance absorption.<br>- Elimination: Primarily excreted in urine via tubular secretion and glomerular filtration.<br>- Half-Life: Approximately 32 hours. |
| Adverse Effects | – TDF: Associated with bone and renal toxicities, including decreased bone mineral density and renal impairment.<br>- TAF: Generally safer with lower nephrotoxicity and bone toxicity compared to TDF.<br>- Common Side Effects: Rash, diarrhea, headache, nausea. |
| Monitoring | – Renal Function: Regular monitoring of renal function, especially in patients with preexisting renal impairment.<br>- Bone Density: Monitoring of bone mineral density in patients on long-term TDF therapy. |
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